Publications by authors named "Mohammadpour Dounighi Nasser"
The Iranian (IEC) venom is an exclusive natural source of bio-substances for a wide range of purposes in the blood coagulation cascade. The present study for the first time was aimed to assess novel pro-coagulant, anti-coagulant and anti-platelet proteins, named EC, EC and EC from Iranian (IEC) venom. These peptides were purified by multi-step chromatography methods.
View Article and Find Full Text PDFBackground: The venom of contains both procoagulant and anticoagulant components that can either promote or block the blood coagulation cascade, and some of these components affect platelet function in different ways.
Objectives: The present study focuses on setting up a procedure for the purification of crude venom and designing appropriate clotting tests in order to characterize the procoagulant and anticoagulant fractions of venom.
Methods: Chromatographic methods, including gel filtration, ion-exchange chromatography, and reverse-phase high-performance liquid chromatography (HPLC), were applied for purifying these fractions.
Serological, pathological, and scintigraphic assessment of effects on renal dysfunction in rats.
Iran J Basic Med Sci
December 2018
Article Synopsis
- The study examines the effects of a dangerous scorpion venom in Iran, focusing on how it can lead to acute kidney injury (AKI), particularly in infants.
- Researchers injected venom into rats and conducted renal scintigraphy along with serological tests to determine the venom's impact on kidney function.
- Findings indicate that while serum indices remained stable, significant kidney damage was observed shortly after envenomation, and renal scintigraphy proved to be an effective, non-invasive method for predicting AKI caused by the scorpion venom.