High-dose amoxicillin and pantoprazole regimen for eradication: a multi-center, multinational randomized controlled trial.

Aim: The aim was to compare the efficacy of high-dose amoxicillin and pantoprazole dual therapy for (HP) eradication in comparison with the clarithromycin-based quadruple regimen.

Material And Methods: The study was designed as a double blind, randomized controlled trial (RCT) on patients with confirmed HP infection referring to 8 medical centers in three countries - Iran, Egypt, and Vietnam - during October 2021 to March 2022. After obtaining written consent, the participants were randomly divided into two groups to receive either high-dose amoxicillin and pantoprazole dual therapy (group A) or the clarithromycin-based quadruple regimen (group B) for 2 weeks and followed by 4 weeks of therapy with pantoprazole.

Design of ELISA-based diagnostic system for detection of enterohaemorrhagic .

Background And Objectives: O157:H7 is an intestinal pathogen of humans and animals, which causes serious gastrointestinal, urinary tract infection and hemolytic uremic syndrome. Connecting to the host cell is important in pathogenesis. EspA, Intimin and Tir proteins (EIT) are the most important bacterial features in the process of binding.

Effect of Helicobacter pylori eradication on metabolic profile: an international, multicenter, case-control study.

Background: As a gram-negative and microaerophilic bacterium, Helicobacter pylori (HP) is the main cause of chronic gastritis. Therefore, considering the high prevalence of HP infection worldwide, as well as the increasing prevalence of metabolic disorders, the present study aimed to investigate the relationship between HP infection eradication and metabolic profile.

Methods: This prospective case-control study was performed on patients with HP infection whom referred to 7 medical centers in 3 countries (Iran, Egypt, and Vietnam) in 2020-2021.