Publications by authors named "Mohammad Aouf"
Comparative analysis of serum SCC antigen levels in inverted sinonasal papilloma and nasal polyps: a diagnostic meta-analysis.
Eur Arch Otorhinolaryngol
August 2025
Purpose: To systematically evaluate the association between serum squamous cell carcinoma antigen (SCCA) levels and Inverted Sinonasal Papilloma (ISP) or nasal polyps (NP), and to determine the diagnostic and prognostic utility of SCCA in these conditions.
Methods: We performed this diagnostic meta-analysis under IRB approval, following the PRISMA and Cochrane guidelines. We searched PubMed, Embase, and Web of Science (January 2004-January 2025) without language restrictions, screened titles and abstracts, and included eight observational studies.
Article Synopsis
- The study aimed to evaluate the effectiveness and safety of budesonide, a steroid injection, for treating chronic rhinosinusitis with nasal polyps (CRSwNP) compared to oral steroids and a control group.
- In a randomized clinical trial with 150 patients, results showed that both budesonide and oral steroids significantly improved symptoms and nasal polyp scores, while the control group did not show significant improvement.
- The conclusion indicates that intrapolyp steroid injections, especially budesonide, are a safe and effective option for patients with recurrent nasal polyps, potentially reducing the need for systemic steroids.
Problem: To assess the efficacy of budesonide intrapolyp injection in chronic rhinosinusitis with nasal polyps.
Method: Ninety patients were divided into three groups; group A was given oral prednisolone, group B was given budesonide intrapolyp injection weekly for five consecutive weeks and group C was given budesonide as nasal irrigation for one month. Patients were assessed using Sino-Nasal Outcome Test 22 score, total nasal polyp score, serum immunoglobulin E, absolute eosinophilic count, and morning cortisol level before treatment, one week and three months after completing their treatment.
Objective: This study compared the efficacy and safety of conventional adenoidectomy using a curette and the Radio-frequency (RF) adenoid ablation using endoscope via the trans-oral technique.
Methods: A randomized prospective comparative study was conducted in a tertiary care hospital. The study included 80 patients with a diagnosis of adenoid hypertrophy, which was confirmed by X-ray of a lateral view of the skull.