Publications by authors named "Mohammad A Alrofaidi"

The suggested study adheres to a particular protocol to ensure that the process is environmentally friendly and sustainable. It is worth mentioning that several tools have been adopted as prospective measures of the method greenness. Fortunately, the established analytical method is identified as white by the white analytical chemistry (WAC) concept, which uses the red/ green/blue color scheme (RGB 12 tool) to combine ecological and functional factors for the first time in studying of the cited drug.

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Article Synopsis
  • - Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting girls, with no effective treatments approved by the USFDA until March 2023, when Trofinetide was finally authorized as the first medication for RTT.
  • - Trofinetide, originally discovered in 2000 by Neuren Pharmaceuticals, is based on a neuroprotective peptide and aims to enhance neuronal structure and function, although its exact mechanism is still unclear.
  • - The approval of Trofinetide marks a significant advancement in RTT treatment, opening doors for further research and clinical trials on related disorders like Fragile X syndrome and autism spectrum disorder.
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Dispersive liquid-liquid microextraction (DLLME) combined with ultra-high performance liquid chromatography-diode array detector (UHPLC-DAD) method has been developed and validated for the determination of parabens in personal care products. In this study, a natural deep eutectic solvent (NADES) composed of menthol and formic acid at a molar ratio of 1 : 2 was prepared and used as an extraction solvent. The influencing variables on the extraction efficiency such as extraction solvent type and volume, composition of NADES, salt addition, vortex and centrifugation time were investigated.

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This study aimed to examine the antidepressant properties of apigenin in an experimental mouse model of chronic mild stress (CMS). Three weeks following CMS, albino mice of either sex were tested for their antidepressant effects using the tail suspension test (TST) and the sucrose preference test. The percentage preference for sucrose solution and the amount of time spent immobile in the TST were calculated.

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