Publications by authors named "Moeko Saito"
Remote ischemic conditioning (RIC) has attracted considerable attention as a brain protection strategy, although its impact remains unclear. Hypothermia is the most effective strategy in experimental transient cerebral ischemia. Therefore, we compared the efficacy of RIC, hypothermia, and no treatment on cerebral ischemia.
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- * In a study involving 648 patients, researchers found that a higher total SVD score was linked to lower scores on cognitive tests like the MMSE and MoCA-J, indicating impaired global cognitive function and attention.
- * The findings suggest that addressing SVD burden could help prevent cognitive decline in affected individuals, highlighting the importance of managing hypertension and other vascular risk factors.
Article Synopsis
- - Remote ischemic conditioning (RIC) shows promise as a method to protect the heart and brain during ischemia, potentially increasing collateral circulation and reducing brain damage after a stroke in mice.
- - In experiments, RIC was found to improve blood flow, decrease early ischemic lesions, and lessen the overall damage to the brain compared to a sham procedure, suggesting its effectiveness in stroke recovery.
- - The beneficial effects of RIC may involve the nitric oxide synthase (NOS) and Akt pathways, as inhibitors of these pathways reversed RIC's positive impacts on circulation and brain injury outcomes.
MRI diffusion-weighted imaging (DWI)-FLAIR mismatch is known as predictive of symptom onset within 4.5 h. This study assessed the breakdown of cytoskeletal protein and blood-brain barrier (BBB) in DWI-T2 mismatch.
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- The study focuses on Southeast Asian mints, which are under-researched yet important in cooking and medicine, examining their genetic diversity and classification.
- Researchers used simple sequence repeat (SSR) markers and leaf morphology to identify two distinct types of mints based on their leaf shape and venation patterns.
- The findings led to the development of 12 SSR markers that allowed for refined classification of these mints into groups, helping to clarify the genetic relationships among known and unclassified mint species.
Background: Remote ischemic conditioning (RIC) refers to the application of repeated short periods of ischemia intended to protect remote areas against tissue damage during and after prolonged ischemia.
Aim: We aim to evaluate the efficacy of RIC, determined by the modified Rankin Scale (mRS) score at 90 days after stroke onset.
Design And Methods: This study is an investigator-initiated, multicenter, prospective, randomized, open-label, parallel-group clinical trial.
Leptomeningeal anastomosis is a key factor for determining early ischemic lesions on diffusion-weighted imaging (DWI) in human stroke. However, few studies have validated this relationship in an experimental model. This study sought to clarify the involvement of leptomeningeal anastomosis in early ischemic lesions using a murine model.
View Article and Find Full Text PDFObjectives: Among several anti-platelet drugs to prevent recurrent stroke, cilostazol has shown various effects besides its anti-platelet activity. We examined whether 7 days of oral administration of cilostazol protects against subsequent cerebral ischemia, and whether or not the effect of combination therapy with aspirin is more protective.
Methods: We used Sprague-Dawley (SD) rats and assigned them to four groups: vehicle, aspirin, cilostazol, and aspirin plus cilostazol combination therapy.
Valproic acid (VPA), widely used in clinical contexts for the treatment of seizures and bipolar mood disorder, has neuroprotective properties in cellular and animal models. However, the precise mechanisms underlying its neuroprotection against stroke remain unknown. In the present study, we explored the effect of VPA on experimental ischemic stroke.
View Article and Find Full Text PDFWe previously reported that the protein transduction domain fused FNK (PTD-FNK) protein, which was derived from anti-apoptotic Bcl-xL protein and thereby gained higher anti-cell death activity, has a strong neuroprotective effect on rat focal brain ischemia models. The aim of this study was to investigate the effect of PTD-FNK protein and hypothermia combined therapy on cerebral infarction. Male SD rats were subjected to 120min middle cerebral artery occlusion (MCAO) with intraluminal thread.
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