The Sm14+GLA-SE Recombinant Vaccine Against and in Adults and School Children: Phase II Clinical Trials in West Africa.

Background/objectives: Following previous successful Phase I clinical trials conducted in men and women in a non-endemic area for schistosomiasis in Brazil, the Sm14 vaccine was evaluated in an endemic region in Senegal. We report successful clinical trials in adults (Phase IIa) and school children (Phase IIb), respectively, of a 14 kDa fatty acid-binding protein (Sm14) vaccine + a glucopyranosyl lipid A (GLA-SE) adjuvant.

Methods: Participants were evaluated based on clinical assessments, laboratory tests (including hematologic and biochemical analyses of renal and hepatic functions), and immunological parameters (humoral and cellular responses) up to 12 months after the first vaccination dose in the Phase IIa trial and after 120 days in the Phase IIb trial.

A Systematic Review of the Impact of Spinal Cord Injury on Costs and Health-Related Quality of Life.

Objective: To systematically review the health-related quality of life (HRQoL) burden and costs of spinal cord injury (SCI) on health services, patients and wider society.

Methods: A systematic review guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement was conducted in March 2021 through Scopus, PubMed and Embase databases. Inclusion criteria were quantitative studies on SCI reporting healthcare costs, social costs and/or HRQoL measured with the Euroqol EQ-5D or Short-Form 36.

High electrochemical performance of nickel cobaltite@biomass carbon composite (NiCoO@BC) derived from the bark of for supercapacitor application.

Biomass carbon-based materials are highly promising for supercapacitor (SC) electrodes due to their availability, environment-friendliness, and low cost. Herein, an easy energy-saving hydrothermal process was used to produce NiCoO/NiOOH (NiCoO) composites with biomass carbon (BC) derived from the bark of (AO) at different synthesis time durations (2 h, 4 h, 8 h, 16 h). The structural and morphological properties of the samples were analysed using XRD, Raman spectroscopy, XPS, SEM, TEM and BET, and the results exhibit the presence of carbon inserted into the nickel-cobalt hydroxide matrix.

Influence of personality traits, gender, and socio-economic factors in obesity in the English Longitudinal Study of Ageing.

Obesity is a chronic disorder associated with high mortality rates and high morbidity. The risk of obesity is associated with certain personality traits (PTs). Some studies have found correlations among some PTs and gender.

[Healthcare access through community-based health insurance among Senegalese migrants].

Objective: To evaluate the determinants of healthcare access financing and the role of a particular class of informal financing known as tontine, a community-based health insurance among Senegalese immigrants.

Method: Data were retrieved through qualitative techniques, semi-structured interviews (n=14) and discussion group (n=10) in a population of Senegalese migrants residing in Granada between October and November 2019. Key participants were from a tontine.

Comparing methods for handling missing cost and quality of life data in the Early Endovenous Ablation in Venous Ulceration trial.

Objectives: This study compares methods for handling missing data to conduct cost-effectiveness analysis in the context of a clinical study.

Methods: Patients in the Early Endovenous Ablation in Venous Ulceration (EVRA) trial had between 1 year and 5.5 years (median 3 years) of follow-up under early or deferred endovenous ablation.

Cost-effectiveness analysis of current varicose veins treatments.

Objective: To analyze the effectiveness and cost effectiveness of technologies for treatment of varicose veins over 5 years-conservative care, surgery (high ligation and stripping), ultrasound-guided foam sclerotherapy (UGFS), endovenous laser ablation (EVLA), and radiofrequency ablation (RFA), mechanochemical ablation (MOCA), and cyanoacrylate glue occlusion (CAE).

Methods: A systematic review was updated and used to construct a Markov decision model. Outcomes were reintervention on the truncal vein, retreatment of residual varicosities and quality-adjusted life years (QALY) and costs over 5 years.