Healthcare debts in the United States: a silent fight.

Healthcare debt in the United States is a significant problem, affecting millions of Americans. Many people struggle to pay for healthcare, and approximately 9% owe over $250 due to health costs. Nearly half of US adults find it difficult to afford healthcare, with uninsured individuals and those with lower incomes facing the most significant challenges.

Predictive identification and design of potent inhibitors targeting resistance-inducing candidate genes from whole-genome sequences.

This work utilizes predictive modeling in drug discovery to unravel potential candidate genes from that are implicated in antimicrobial resistance; we subsequently target the gidB, MacB, and KatG genes with some compounds from plants with reported antibacterial potentials. The resistance genes and plasmids were identified from 10 whole-genome sequence datasets of ; forty two plant compounds were selected, and their 3D structures were retrieved and optimized for docking. The 3D crystal structures of KatG, MacB, and gidB were retrieved and prepared for molecular docking, molecular dynamics simulations, and ADMET profiling.