Publications by authors named "Mobin Mohamadi"
Background: It is widely recognized that obesity is characterized by a chronic low-grade inflammatory condition. In the context of childhood and adolescent obesity, there is also a noteworthy correlation with elevated levels of inflammatory markers. These markers signify a proinflammatory state that may have relevance to the development of MS.
View Article and Find Full Text PDFPrevalence, risk factors, natural history, and prognostic significance of Modic changes in the cervical spine: a comprehensive systematic review and meta-analysis of 12,754 participants.
Neurosurg Rev
August 2024
Objective: Modic changes (MCs) in the cervical spine are common, but remain an under-researched phenomenon, particularly regarding their prevalence, natural history, risk factors, and implications for surgical outcomes. This systematic review and meta-analysis endeavors to elucidate the multifactorial dimensions and clinical significance of cervical MCs.
Methods: Following PRISMA guidelines, a comprehensive systematic search was performed using Medline (via PubMed), EMBASE, Scopus, and Web of Science databases from their dates of inceptions to September 4, 2023.
Background: In this systematic review and meta-analysis, we aimed to investigate the correlation between disability in patients with Multiple sclerosis (MS) measured by the Expanded Disability Status Scale (EDSS) and brain Magnetic Resonance Imaging (MRI) features to provide reliable results on which characteristics in the MRI can predict disability and prognosis of the disease.
Methods: A systematic literature search was performed using three databases including PubMed, Scopus, and Web of Science. The selected peer-reviewed studies must report a correlation between EDSS scores and MRI features.
Article Synopsis
- This study is a systematic review investigating the link between pre-operative diffusion tensor imaging (DTI) metrics and post-operative outcomes in patients with degenerative cervical myelopathy (DCM).
- The review found that fractional anisotropy (FA) was significantly correlated with post-operative improvement, particularly in patients aged 65 and older, while the apparent diffusion coefficient (ADC) showed a relationship with recovery rate across all ages.
- Despite these findings, the authors concluded that more evidence is needed to confirm whether DTI metrics can reliably predict post-operative recovery, which could aid in selecting candidates for surgery.*
The association between multiple sclerosis and migraine: A meta-analysis.
Mult Scler Relat Disord
November 2023
Background: Multiple sclerosis (MS) is a chronic progressive condition marked by the deterioration of myelin and impairment of neurological function. The global prevalence of MS is approximately 2.2 million.
View Article and Find Full Text PDFEfficacy and safety of rituximab in multiple sclerosis: a systematic review and meta-analysis.
Acta Neurol Belg
December 2023
Objective: We aimed to synthesize all available observational studies and clinical trials of rituximab to estimate the safety and efficacy of this monoclonal antibody in people with multiple sclerosis (MS).
Methods: The four databases including PubMed, Scopus, Embase, and Web of Science were comprehensively searched in April 2022. We defined PICO as follows.
Frailty is a known predictor of negative health outcomes. The role of frailty in predicting outcomes after traumatic brain injury (TBI), however, is unclear. This systematic review aimed to evaluate the association between frailty and adverse outcomes in patients with TBI.
View Article and Find Full Text PDFBackground: Previously, several studies investigated the effect of cladribine among patients with multiple sclerosis (MS) as a treatment option. Due to the contradictory results of previous studies regarding the efficacy and safety of cladribine in the MS population, we aimed to conduct a systematic review and meta-analysis by including clinical trials and observational studies in terms of having more confirmative results to make a general decision.
Methods: The three databases including PubMed, Scopus, and Web of Science were comprehensively searched in May 2022.