Oxidative DNA Damage and Apoptosis Induced by Aclarubicin, an Anthracycline: Role of Hydrogen Peroxide and Copper.

Background/aim: This study aimed to investigate aclarubicin (ACR)-induced oxidative DNA damage and apoptosis.

Materials And Methods: ACR-induced apoptosis was analyzed using HL-60 leukemia cells and HP100 cells, hydrogen peroxide (HO)-resistant cells derived from HL-60 cells. ACR-induced DNA damage was analyzed using plasmid DNA.