Publications by authors named "Mitchell D Plesser"
Article Synopsis
- Encapsulation and transplantation of insulin-producing cells offer a potential cure for type 1 diabetes (T1D) without the need for immunosuppressive drugs, but existing biomaterials often cause harmful reactions that can hinder effectiveness.
- A new nanofibrous device has been developed, featuring a thin alginate hydrogel coating that reduces fibrotic responses and enhances mass transfer, allowing for better cell function.
- The device has shown promising results in long-term diabetes correction in mice and demonstrates the ability to scale and be retrieved, indicating its potential for clinical applications in T1D and other diseases.
Islet transplantation is a promising long-term, compliance-free, complication-preventing treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow set of patients due to the shortage of donor islets and side effects from immunosuppression. Encapsulating cells in an immunoisolating membrane can allow for their transplantation without the need for immunosuppression.
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