Pre- and Postnatal Fine Particulate Matter Exposure and Renal Fibrogenesis in Adult Male Rats: The Role of Vitamin D Supplementation.

Prolonged exposure to fine particulate matter (PM) has been implicated in accelerated aging, including organ fibrosis. This study aimed to investigate whether prenatal and postnatal PM exposure promotes renal fibrogenesis in adulthood and whether long-term vitamin D supplementation alleviates associated renal injury. Pregnant Sprague-Dawley rats were randomly assigned to three groups: control (normal saline, NS), PM exposure, and PM exposure with vitamin D supplementation during gestation and lactation ( = 3/group).

Long-Term Alterations of Renal Microvasculature in Rats Following Maternal PM Exposure: Vitamin D Effects.

: This study aimed to investigate the long-term effects of maternal exposure to fine particulate matter (PM) with or without vitamin D supplementation on the renal microvasculature in adult rat offspring. : Pregnant Sprague-Dawley rats were exposed to normal saline, PM, and PM with vitamin D for one month during nephrogenesis. Male offspring kidneys were taken for analyses on postnatal day 56.

Combined nutcracker syndrome and glomerulonephritis in pediatric patients: a single-center retrospective case series.

Background: Nutcracker syndrome (NCS) has been reported to coexist with various glomerulonephritis (GN). This study investigated clinical features of NCS combined with GN in a pediatric case series and the possible relationship between these two conditions.

Methods: Clinical and pathologic findings of 15 children with NCS and biopsy-proven GN were analyzed.

Urine specific gravity, pyuria, and neutrophil gelatinase-associated lipocalin for identifying urinary tract infection in young children.

Background: To determine whether urine neutrophil gelatinase-associated lipocalin (uNGAL) might be superior to pyuria for detecting urinary tract infection (UTI) regardless of urine specific gravity (SG) in young children.

Methods: We conducted a retrospective analysis of children aged < 3 years who were evaluated for UTI with urinalysis, urine culture, and uNGAL measurements during a 5-year period. Sensitivity, specificity, likelihood ratios (LRs), predictive values (PVs), area under the curves (AUCs) of uNGAL cut-off levels, and various microscopic pyuria thresholds for detecting UTI were calculated for dilute (SG < 1.

Exposure to airborne particulate matter induces renal tubular cell injury : the role of vitamin D signaling and renin-angiotensin system.

Background: Exposure to air pollution can interfere with the vitamin D endocrine system. This study investigated the effects of airborne particulate matter (PM) on renal tubular cell injury and explored the underlying mechanisms.

Methods: HK-2 human renal proximal tubule cells were treated with PM with or without 1,25(OH)D analog, 19-Nor-1,25(OH)D (paricalcitol, 10 nM) for 48 h.