Publications by authors named "Milo Giani"
Background: Adenomyosis is a uterine disorder causing menstruation-related symptoms such as dysmenorrhea, heavy menstrual bleeding (HMB) and dyspareunia. A long-term management of the disease is required. Hormonal drugs are the most used, including a variety of progestins, even though few data are available on their long-term use in adenomyosis.
View Article and Find Full Text PDFSelective progesterone receptor modulators for the treatment of dysmenorrhea: an update.
Expert Opin Pharmacother
February 2025
Introduction: Dysmenorrhea is a painful symptom associated with uterine contractions and menstrual bleeding and is treated by administering analgesic drugs. Since progesterone receptors (PRs) have a major role in regulating uterine tissues (myometrium and endometrium) physiology, oral contraceptives are used off-label for treating primary or secondary dysmenorrhea. The development of selective progesterone receptor modulators (SPRMs), a class of synthetic steroids with agonistic, antagonistic, or mixed effects in targeting PRs in different tissues, stimulated their possible clinical use for treating secondary dysmenorrhea related to uterine diseases (endometriosis, adenomyosis, uterine fibroids).
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- This study looks at how well ultrasound can detect parametrial endometriosis in patients who need surgery. !*
- Researchers used a special method to check patients for endometriosis before their operations and compared the ultrasound results to what was found during surgery. !*
- They found that the ultrasound was pretty good at detecting this condition, with a sensitivity of 77.1% and a high specificity of 99.1%, and most of the detected nodules were usually located in the back area of the reproductive organs. !*
Article Synopsis
- Sentinel lymph node biopsy (SLNB) has shifted from using intraoperative frozen section (FS) to delayed permanent section (PS) analysis for breast cancer staging, with FS used selectively for high-risk cases.
- A study analyzed data from 2004 to 2020, revealing that switching to PS dramatically reduced the need for subsequent axillary dissection and decreased operative time without affecting re-operation rates or survival outcomes.
- The findings suggest that PS-SLNB is a safer and more efficient approach, offering both patient and healthcare system benefits while maintaining the same survivorship and recurrence rates.
Article Synopsis
- The FGD3 gene is emerging as a promising prognostic factor for breast cancer, as it helps improve outcomes by inhibiting cell migration.
- In a study of 401 women with invasive breast cancer, high expression of FGD3 was linked to significantly better disease-free survival (DFS) and overall survival (OS).
- FGD3 expression proved to be a stronger prognostic indicator than traditional factors like histological grade and molecular subtype, suggesting it could enhance patient risk stratification in clinical practice.*
Long-term Results After Neoadjuvant Chemotherapy for Breast Cancer: A Single-center Experience.
Anticancer Res
February 2020
Background/aim: We evaluated the efficacy of neoadjuvant chemotherapy (NACT) in reducing locally-advanced breast cancer (LABC) size, thus improving breast-conserving surgery (BCS) rates, as well as its long-term outcome.
Patients And Methods: We analyzed 59 patients treated between 1999-2017 with NACT and subsequent surgery for LABC.
Results: We observed a tumor size reduction in 95% of cases, resulting in downstaging in 62.
Background/aim: Recently, "conservative" mastectomy with immediate breast reconstruction (M-R) has become the gold standard when the breast must be removed. We analyzed the evolution in the choice of mastectomy type in our Unit, focusing on factors associated with renounce to reconstruction and risk factors for its failure.
Patients And Methods: Clinical-pathological and surgical features of 132 patients who underwent mastectomy in our Unit from 2004 to 2016 were analyzed.