Evaluation of Outpatient Antibiotic Prescribing for Urinary Tract Infection in Pediatric Patients Ages 2 Months to 18 Years.

Objective: To characterize the diagnosis and management of urinary tract infection (UTI) in pediatric patients at the University of Illinois Hospital and Health Sciences System (UIH), with an emphasis on antibiotic prescribing; in addition, to characterize pediatric uropathogen patterns to help guide future empiric therapy choices.

Methods: We used a retrospective, descriptive study of pediatric patients ages 2 months to ≤18 years seen at the UIH emergency department or clinic from January 1, 2014, to August 31, 2018, with ICD-9 or ICD-10 discharge diagnosis of UTI. Data collected included presenting symptoms, urinalysis, details of antibiotic regimens, urine culture, and susceptibility results.

The clinical spectrum of SMA-PME and in vitro normalization of its cellular ceramide profile.

Objective: The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.

Methods: Clinical features of 6 patients with SMA-PME were assessed by retrospective chart review, and a literature review of 24 previously published cases was performed. Leukocyte enzyme activity of acid ceramidase was assessed with a fluorescence-based assay.

Interventions involving spiritual and religious themes in pharmacy student patient encounters during advanced practice rotations.

Introduction: Patient spiritual and religious beliefs can impact their health care choices and outcomes. Pharmacists and other health care providers need to be prepared when these beliefs present changes from usual medical care. The objective of this research brief was to describe interventions related to spirituality and/or religion that are encountered by students during advanced pharmacy practice experience (APPE) patient care activities.

Stereotypes About Political Attitudes and Coalitions Among U.S. Racial Groups: Implications for Strategic Political Decision-Making.

What are people's expectations of interracial political coalitions? This research reveals expectations of flexible interracial coalitions stemming from how policies and racial groups are viewed in terms of perceived status and foreignness. For policies seen as changing societal status (e.g.

Frequency, setting and influential factors associated with pharmacy student-patient encounters involving spirituality and religiosity during advanced practice rotations.

Introduction: To identify (1) how often and in what settings pharmacy students include spirituality and religion and (2) what factors may influence how often students incorporate spirituality in patient care plans.

Methods: Fourth-year pharmacy students completed a questionnaire defining the frequency and setting of patient care activities that incorporated spiritual beliefs during advanced pharmacy practice experiences. Demographics, prior spirituality and health coursework, and self-identified measures of religiosity and spirituality were collected.

Human embryoid bodies as a 3D tissue model of the extracellular matrix and α-dystroglycanopathies.

The basal lamina is a specialized sheet of dense extracellular matrix (ECM) linked to the plasma membrane of specific cell types in their tissue context, which serves as a structural scaffold for organ genesis and maintenance. Disruption of the basal lamina and its functions is central to many disease processes, including cancer metastasis, kidney disease, eye disease, muscular dystrophies and specific types of brain malformation. The latter three pathologies occur in the α-dystroglycanopathies, which are caused by dysfunction of the ECM receptor α-dystroglycan.

Evaluating the Transition From Dexmedetomidine to Clonidine for the Prevention of Withdrawal in Critically Ill Pediatric Patients.

Objectives: To evaluate clonidine for preventing withdrawal from dexmedetomidine infusions and describe the incidence of withdrawal symptoms and adverse cardiovascular effects in critically ill pediatric patients.

Methods: Retrospective, descriptive study of patients in Advocate Children's Hospital-Park Ridge PICU who received dexmedetomidine infusion for ≥72 hours, followed by clonidine for ≥48 hours, between January 1, 2015, and August 31, 2017.

Results: Thirty-eight patients (median age 4.

Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells.

Efficient and homogeneous in vitro generation of peripheral sensory neurons may provide a framework for novel drug screening platforms and disease models of touch and pain. We discover that, by overexpressing NGN2 and BRN3A, human pluripotent stem cells can be transcriptionally programmed to differentiate into a surprisingly uniform culture of cold- and mechano-sensing neurons. Although such a neuronal subtype is not found in mice, we identify molecular evidence for its existence in human sensory ganglia.

Readiness for Clinical Practice Promoting Safe Student Performance in Physical Therapy Education.

Background: Physical therapy educators have a responsibility to graduate entry-level PTs who can provide safe high-quality care. The main purpose of this retrospective study was to determine if students who were not safe on campus have different midterm Clinical Performance Instrument (CPI) safety scores on clinical education experiences (CEEs) than students who were safe on campus.

Methods: Forty-six DPT students were categorized into two safety groups: (1) students who were not safe on campus and had successful safety remediation (n=17) and (2) students who were safe on campus (n=29).

Self-Perceived Knowledge, Skills, Attitudes, and Use of Evidence-Based Dentistry Among Practitioners Transitioning to Dental Educators.

Dental practitioners transitioning to dental educators (PTEs) have an integral role in dental education. While PTEs intrinsically apply some form of evidence-based dentistry (EBD) in patient care, it may not be a standardized, systematic approach. The aims of this study were to determine the self-perceived knowledge, skills, attitudes, and behaviors of PTEs regarding EBD at one U.

Professionalism in Physician Assistant, Physical Therapist, Occupational Therapist, Clinical Psychology, and Biomedical Sciences Students.

Unlabelled: Interprofessional collaboration for healthcare requires a better understanding of the commonalities and differences in student perceptions of professionalism.

Methods: 217 students in five programs (PA 71, PT 46, OT 29, CP 12, and BMS 59) completed a 22-item survey (response rate 79.5%).

Blood gene signature for early hepatocellular carcinoma detection in patients with chronic hepatitis B.

Purpose: Up to 25% of chronic hepatitis B (CHB) patients eventually develop hepatocellular carcinoma (HCC), a disease with poor prognosis unless detected early. This study identifies a blood-based RNA biomarker panel for early HCC detection in CHB.

Materials And Methods: A genome-wide RNA expression study was performed using RNA extracted from blood samples from Malaysian patients (matched HCC, CHB, controls).

National survey of occupational therapy practitioners' involvement in response to intervention.

OBJECTIVE. We sought to describe occupational therapy practitioners' perceived levels of preparedness for and involvement in school-based Response to Intervention (RtI) initiatives. METHOD.

Whole blood transcriptome correlates with treatment response in nasopharyngeal carcinoma.

Background: Treatment protocols for nasopharyngeal carcinoma (NPC) developed in the past decade have significantly improved patient survival. In most NPC patients, however, the disease is diagnosed at late stages, and for some patients treatment response is less than optimal. This investigation has two aims: to identify a blood-based gene-expression signature that differentiates NPC from other medical conditions and from controls and to identify a biomarker signature that correlates with NPC treatment response.

Montessori-Based Activities as a Trans-Generational Interface for Persons with Dementia and Preschool Children.

Montessori-based activities for persons with dementia have been used to successfully provide opportunities for programming between older adults and preschool children in shared site. intergenerational care programs. Such intergenerational programming allows older adults with dementia to fulfill roles of teacher or mentor to younger children or as collaborative workmates for persons with more advanced dementia while providing children with positive one-on-one interactions with older adults.

Age differences in visual statistical learning.

Recent work has shown that older adults' lessened inhibitory control leads them to inadvertently bind co-occurring targets and distractors. Although this hyper-binding effect may lead to the formation of more superfluous associations, and thus greater interference at retrieval for older adults, it may also lead to a greater knowledge of information contained within the periphery of awareness. On the basis of evidence that younger adults only show learning for statistical regularities contained within attended information, we asked whether older adults may also show learning for regularities contained within to-be-ignored information.

Use of a common laboratory glassware detergent improves recovery of Cryptosporidium parvum and Cyclospora cayetanensis from lettuce, herbs and raspberries.

The success of any protocol designed to detect parasitic protozoa on produce must begin with an efficient initial wash step. Cryptosporidium parvum and Cyclospora cayetanensis oocysts were seeded onto herbs, lettuces and raspberries, eluted with one of four wash solutions and the recovered number of oocysts determined via fluorescent microscopy. Recovery rates for fluorescein thiosemicarbazide labeled C.

Effects of intergenerational Montessori-based activities programming on engagement of nursing home residents with dementia.

Fourteen nursing home residents on a dementia special care unit at a skilled nursing facility took part in one-to-one intergenerational programming (IGP) with 15 preschool children from the facility's on-site child care center. Montessori-based activities served as the interface for interactions between dyads. The amount of time residents demonstrated positive and negative forms of engagement during IGP and standard activities programming was assessed through direct observation using a tool developed for this purpose--the Myers Research Institute Engagement Scale (MRI-ES).

Executive Functions in Persons with Sleep Apnea.

Seventeen patients with sleep apnea syndrome [SAS, Respiratory Disturbance Index (RDI) = 12-85] were compared with 16 normal controls (RDI < 7) on neuropsychological tests of executive functions, a domain in which SAS patients have been suggested to have deficits. SAS patients demonstrated greater deficits in the retrieval of information from semantic memory (Controlled Oral Word Association task) and in shifting responses in the face of error (Wisconsin Card Sort Test), but differences in working memory were not observed. Eliciting deficits in cognitive executive functions in SAS may require more sensitive measures than are typically used in neuropsychiatric research.