Publications by authors named "Michael Wing-Yan Chan"
Background: The σ factor in Staphylococcus aureus governs the environmental stress response and a wide spectrum of biological functions. σ activity is regulated by protein-protein interactions among RsbU, RsbV, RsbW, and σ. While the C-terminal PP2C phosphatase domain of RsbU is well-characterized, the function of its N-terminal domain remains unclear.
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- The study investigates how hepatocellular carcinoma (HCC) adapts to resistance against anti-PD-L1 immunotherapies, revealing the importance of tumour microenvironment remodelling.
- Researchers created resistant HCC models and used advanced techniques like single-cell RNA sequencing to explore the mechanisms of resistance, finding that certain immune cells (MDSCs) grow alongside tumours and suppress the immune response.
- The research identified a specific pathway involving PPARγ, which enhances VEGF-A production, leading to immune dysfunction and poor patient outcomes, suggesting that targeting this pathway could potentially enhance the effectiveness of immunotherapies.
Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer.
Microbiome
July 2020
Article Synopsis
- The study examines the link between changes in gut bacteria and DNA methylation of tumor suppressor genes (TSGs) in colorectal cancer (CRC) using genetic sequencing on tissue biopsies from various stages of the disease.
- Researchers found that the bacteria Fusobacterium nucleatum and Hungatella hathewayi contribute to increased DNA methylation, which can regulate the expression of important TSGs like CDX2 and MLH1.
- The findings suggest that these bacteria promote CRC by activating DNA methyltransferases, leading to enhanced cell proliferation in the colonic tissue.
Ovarian high-grade serous carcinoma (HGSC) is the most lethal gynecological malignancy. Prevailing evidences suggest that drug resistance and recurrence of ovarian HGSC are caused by the presence of cancer stem cells. Therefore, targeting cancer stems is appealing, however, all attempts to date, have failed.
View Article and Find Full Text PDFAberrant epigenetic modifications in radiation-resistant head and neck cancers.
Methods Mol Biol
July 2015
Head and neck cancers are characterized by both genetic and epigenetic aberrations. In treating head and neck cancers, ionizing radiation (IR) is an essential modality in either definitive or adjuvant setting. However, radiation-resistant head and neck cancers are not uncommon.
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