Incomplete Cancer Surgery Correlates With Loss of Immune Surveillance and Hyper-Progression of Disease.

Background: Surgery is potentially curative for solid cancers; however, in cases of incomplete surgery, the impact of surgery on immune surveillance in the residual tumor microenvironment is not known. We sought to understand how surgery impacts immune populations in a residual tumor and correlates with overall survival in patients with primary pleomorphic liposarcoma.

Methods: This retrospective cohort study was conducted by searching the UCLA Sarcoma Program database for all patients with a histologic diagnosis of primary pleomorphic liposarcoma from 1995 to 2015.

Sarcoma in patients with Lynch syndrome and response to immunotherapy.

Background: Lynch syndrome (LS) is an autosomal dominant genetic predisposition to multiple malignancies and is characterized by deficient DNA mismatch repair. Increased incidence of sarcomas is not formally ascribed to LS; however, increasing evidence suggests a preponderance of these malignancies in affected families. Sarcomas typically possess a low tumor mutational burden and incite a poor immune infiltrate, thereby rendering them poorly responsive to immunotherapy.

Cancer-Associated B Cells in Sarcoma.

Despite being one of the first types of cancers studied that hinted at a major role of the immune system in pro- and anti-tumor biology, little is known about the immune microenvironment in sarcoma. Few types of sarcoma have shown major responses to immunotherapy, and its rarity and heterogeneity makes it challenging to study. With limited systemic treatment options, further understanding of the underlying mechanisms in sarcoma immunity may prove crucial in advancing sarcoma care.