Publications by authors named "Michael Papazian"

Objectives: To characterize treatment and hearing outcomes for cerebellopontine angle (CPA) meningiomas with inherent risks of hearing loss and identify predictors of hearing loss for surgically treated lesions.

Design: Retrospective chart review.

Setting: Tertiary care medical center.

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Objectives: To assess a decade of experience of treating patients with high hearing risk cerebellopontine angle (CPA) epidermoid lesions and examine factors influencing postoperative outcomes, particularly hearing preservation.

Study Design: Retrospective chart review.

Setting: Single tertiary-referral center.

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Objective: Facial trauma volume is difficult to predict accurately. We aim to understand the capacity of climate and regional events to predict daily facial trauma volume. This can provide epidemiologic understanding and subsequently tailor workforce distribution and scheduling.

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Importance: In addition to their patient management value, multidisciplinary tumor boards have been recognized as effective learning tools. However, the value of using a virtual tumor board as a learning tool for head and neck surgical oncology fellows has not been studied.

Objective: To describe the structure and content of the American Head and Neck Society (AHNS) Virtual Tumor Board and assess its educational value as perceived by attendees.

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Objective: To compare treatment outcomes for T4b head and neck adenoid cystic carcinoma (ACC).

Study Design: Historical cohort study.

Setting: National Cancer Database (NCDB).

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Background: There are several options for primary surgical treatment of early-stage supraglottic squamous cell carcinoma (SCC), including transoral robotic surgery (TORS). The purpose of this study was to compare outcomes of TORS to open partial laryngectomy and transoral laser microsurgery (TLM).

Methods: Patients with clinical classification T1-2 supraglottic SCC diagnosed 2010-2019, treated with TORS, open partial laryngectomy, or TLM in the National Cancer Database were selected.

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Importance: Over time, the American Thyroid Association (ATA) guidelines have increasingly promoted more limited treatments for well-differentiated thyroid cancers.

Objective: To determine whether the 2009 and 2015 ATA guidelines were associated with changes in the management of low-risk papillary thyroid carcinomas on a national scale.

Design, Setting, And Participants: This historical cohort study used the National Cancer Database.

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Background: Proper connectivity between type I spiral ganglion neurons (SGNs) and inner hair cells (IHCs) in the cochlea is necessary for conveying sound information to the brain in mammals. Previous studies have shown that type I SGNs are heterogeneous in form, function and synaptic location on IHCs, but factors controlling their patterns of connectivity are not well understood.

Results: During development, cochlear supporting cells and SGNs express Semaphorin-3A (SEMA3A), a known axon guidance factor.

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Sinonasal undifferentiated carcinoma (SNUC) is a rapidly growing malignancy with a propensity for extensive local invasion. Multimodal therapy, including surgery, radiotherapy, and chemotherapy, is the standard approach to treatment, but the optimal sequence and combination of these modalities are uncertain. Induction chemotherapy is being increasingly utilized based on recent reports that show better outcomes for patients who respond to chemotherapy and the ability to determine further course of treatment.

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Sinonasal glomangiopericytoma is a rare vascular tumor of the respiratory epithelium. Treatment consists mainly of surgical resection, though there is no consensus regarding the use of adjuvant therapies or preoperative endovascular embolization. The postsurgical prognosis is favorable, though there is a high risk of delayed recurrence.

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Article Synopsis
  • - The study examined outcomes for patients with indeterminate thyroid nodules (ITNs) who underwent repeat fine-needle aspiration (FNA) biopsy and genomic testing to improve diagnosis and treatment decisions.
  • - Out of 96 patients reviewed, the repeat FNA led to 42% of nodules being reclassified as benign, with most nodules downgraded to non-surgical management, significantly reducing the need for surgery.
  • - Patients with positive ThyroSeq results were more likely to undergo surgery, though the overall risk of high-risk malignancy in these cases was found to be low.
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Importance: Genomic classifiers were developed to better guide clinicians in the treatment of indeterminate thyroid nodules (ITNs). To our knowledge, whether there is variation in the diagnostic accuracy of these tests depending on ITN size has not been previously studied.

Objective: To analyze the diagnostic performance of a genomic classifier in relation to ITN size.

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