Publications by authors named "Michael D Conroy"
Adenosine monophosphate-activated kinase (AMPK) plays a central role in regulating energy homeostasis in eukaryotic cells. AMPK also regulates lipid synthesis by inhibiting acetyl-CoA carboxylase (ACC) and regulates mTOR signaling by activating TSC2. Due to its important roles in cell metabolism, AMPK is an attractive target for metabolic diseases, such as type II diabetes and obesity.
View Article and Find Full Text PDFArticle Synopsis
- Traumatic brain injury (TBI) from blast exposure is common in military populations, with unclear underlying mechanisms affecting brain function.
- Researchers used a shock tube to expose rats to blast conditions, finding initial neurological impairment and temporary increases in blood-brain barrier (BBB) permeability.
- Key findings included significant oxidative stress markers peaking at 3 hours post-exposure, gradual normalization by 24 hours, and microglia activation in specific brain regions over the following days, suggesting these factors contribute to TBI-related neuropathology.