Publications by authors named "Mi-Hye Mun"
Short rare minisatellite variant of BORIS-MS2 is related to bladder cancer susceptibility.
Genes Genomics
February 2019
Background: BORIS/CTCFL, a paralog of CTCF and member of the cancer-testicular antigen family, is abnormally activated in multiple cancers.
Objective: We investigated the relationship between polymorphic variants of the BORIS minisatellite 2 (BORIS-MS2), located within the 5' upstream promoter region of BORIS, and bladder cancer.
Methods: We used case-control study with 516 controls and 113 bladder cancer patients.
Article Synopsis
- Recurrence of bladder cancer is linked to the proliferation of drug-resistant cells, particularly through mechanisms involving drug efflux.
- Previous studies have highlighted the FOXM1 gene as a critical factor in this process, where inhibiting FOXM1 reduces drug efflux and enhances the effectiveness of Doxorubicin.
- The study identifies the ABCG2 gene, associated with drug efflux, as a target regulated by FOXM1, indicating that targeting both FOXM1 and ABCG2 could improve treatment strategies for bladder cancer.
The dopamine transporter SLC6A3 (DAT1) mediates uptake of dopamine into presynaptic terminals. In addition, in previous reports, hypertensive rats were associated with DAT gene, but the genetic association with SLC6A3 and hypertension is still unknown. We examined the distribution of variable number of tandem repeats (VNTRs) and conducted polymorphic analysis of the entire region of SLC6A3.
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