High intake of n-6 polyunsaturated fatty acid exacerbates non-alcoholic steatohepatitis by the involvement of multiple metabolic pathways.

Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, inflammation, and hepatocyte damage. A Western-style diet characterized by excessive n-6 polyunsaturated fatty acid (n-6 PUFA) intake, which is metabolized to pro-inflammatory arachidonic acids (AAs), might contribute to the exacerbation of NASH. Investigating the interactive effects of choline deficiency and n-6 PUFA supplementation on NASH progression, we aimed to elucidate how AA metabolites, such as leukotrienes, prostaglandins, and the CYP2J3/epoxyeicosatrienoic acids (EET) pathway influence disease pathogenesis.

Value of serum free prostate-specific antigen density in the diagnosis of prostate cancer.

Purpose: To investigate the value of serum free prostate-specific antigen density (fPSAD) in the diagnosis of prostate cancer (PCa).

Methods: The data of 558 patients who underwent transrectal ultrasound-guided prostate biopsy were retrospectively analyzed. According to the pathological results, the patients were divided into a PCa group and a benign prostatic hyperplasia (BPH) group.

Reconfigurable electro-optical logic gates using a 2-layer multilayer perceptron.

In this work, we aim to use the optical amplifiers, directional couplers and phase modulators to build the electro-optical gates. Thanks to the 2-layer-multilayer-perceptron structure, the inversion of matrix is performed to obtain the coupling ratio of the directional couplers and the phase delay of the phase modulators. The electro-optical OR, AND, XOR, NAND, NOR and XNOR gates are demonstrated.

Liver X receptors agonist T0901317 exerts ferroptosis sensitization in cancer.

Numerous studies have confirmed the anticancer effects of ferroptosis on a wide range of tumors, specifically in providing new perspectives for tackling drug resistance and treating refractory tumors. Notably, mechanisms of improving tumor susceptibility to ferroptosis have been a focus of current research. This study discovered that co-treatment of LXRS agonist T0901317 and ferroptosis inducers (FINs) significantly inhibited the proliferation of cancer cells, this inhibition effect could be reversed by specific inhibitors of ferroptosis and accompanied by elevated lipid peroxides.

A juvenile hormone transcription factor Bmdimm-fibroin H chain pathway is involved in the synthesis of silk protein in silkworm, Bombyx mori.

The genes responsible for silk biosynthesis are switched on and off at particular times in the silk glands of Bombyx mori. This switch appears to be under the control of endogenous and exogenous hormones. However, the molecular mechanisms by which silk protein synthesis is regulated by the juvenile hormone (JH) are largely unknown.

Basic helix-loop-helix transcription factor Bmsage is involved in regulation of fibroin H-chain gene via interaction with SGF1 in Bombyx mori.

Silk glands are specialized in the synthesis of several secretory proteins. Expression of genes encoding the silk proteins in Bombyx mori silk glands with strict territorial and developmental specificities is regulated by many transcription factors. In this study, we have characterized B.