Exploring the Mechanism of Surface Cationic Vacancy Induces High Activity of Metastable Lattice Oxygen in Li- and Mn-Rich Cathode Materials.

Li- and Mn-rich layered oxides exhibit high specific capacity due to the cationic and anionic reaction process during high-voltage cycling (≥4.6 V). However, they face challenges such as low initial coulombic efficiency (~70 %) and poor cycling stability.

Nanograin-Boundary-Abundant CuO-Cu Nanocubes with High C Selectivity and Good Stability during Electrochemical CO Reduction at a Current Density of 500 mA/cm.

Surface and interface engineering, especially the creation of abundant Cu/Cu interfaces and nanograin boundaries, is known to facilitate C production during electrochemical CO reductions over copper-based catalysts. However, precisely controlling the favorable nanograin boundaries with surface structures (e.g.

NAT2 fast acetylator genotype and MGMT promoter methylation may contribute to gender difference in K-RAS mutation occurrence in Taiwanese colorectal cancer.

A recent study conducted by our group showed that the NAT2 fast acetylator genotype is associated with an increasing risk for the development of colorectal cancer (CRC), especially for females. We therefore examined whether a higher risk of CRC in females with the NAT2 fast acetylator genotype was associated with the occurrence of K-RAS mutation, and to further verify whether MGMT promoter methylation was linked to the occurrence of K-RAS mutation in patients with the NAT2 fast acetylator genotype. Herein, 151 CRC cases were examined for NAT2 genetic polymorphisms and MGMT promoter methylation by PCR-RFLP and methylation-specific PCR (MSP).

NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan.

In Taiwan, colorectal cancer has one of the highest rates of increased incidence in the past two decades. Heterocyclic amines from dietary cooked meats are metabolically activated by NAT2 (N-acetyltransferase 2), which are associated with colorectal cancer incidence. Thus, the NAT2 fast acetylator genotype may be associated with colorectal cancer risk.

Different p53 mutation patterns in colorectal tumors from smokers and nonsmokers.

Epidemiological studies consistently find associations between colorectal cancer and cigarette smoking; however, there are little molecular data supporting the association. To examine the relationship between cigarette smoking and colorectal cancer, we compared p53 mutation patterns in colorectal tumors from smokers and nonsmokers. In this study, 153 tumor tissues from colorectal cancer patients, including 63 smokers and 90 nonsmokers, were examined for p53 mutation and p53 protein expression by direct sequencing and immunohistochemistry (IHC), respectively.