Subacute thyroiditis as a post-COVID-19 complication: a systematic review.

Introduction: The emergence of Subacute Thyroiditis (SAT) in the wake of COVID-19 has presented a unique set of challenges for clinicians and researchers. This study delves into the intricate interplay between COVID-19 and SAT, examining a wealth of cases from observational studies.

Methods: We conducted a comprehensive literature review utilizing PubMed/MEDLINE, EMBASE, and Scopus databases, encompassing studies available up to January 2, 2025.

Evaluation of the antagonistic effect of toxins on azole antifungal resistance in species isolated from clinical samples in Iran.

Background And Objectives: The azole antifungals are the most frequent class used to treat infections. It is essential to elucidate the potential of natural compounds as an alternative in eliminating Therefore, in the present study, the antagonistic effect of toxins on azole antifungal resistance in species was investigated.

Materials And Methods: In this study, 28 species with azole antifungal resistance were obtained from patients at Shohadaye Tajrish Hospital.

The antioxidant and anticonvulsant effects of ellagic acid in kainic acid-induced temporal lobe epilepsy in mice.

Oxidative stress (OS) resulting from high levels of free radicals contributes to the initiation and progression of epilepsy. Temporal lobe epilepsy (TLE) is associated with alteration in the structure and function of the hippocampus and is modeled in mice using kainic acid (KA). In this study, the neuroprotective effect of ellagic acid (EA) on KA-induced epilepsy in mice was evaluated.

Unveiling the Genetic Landscape of Isolated From Hospital Wastewaters: Emergence of Hypervirulent CC8 Strains in Tehran, Iran.

Multidrug-resistant bacteria and priority pathogens, including MRSA, are frequently found in hospital wastewaters. It is crucial to investigate the genetic diversity, biofilm formation, and virulence analysis of isolated from hospital wastewaters. In this cross-sectional study, 70 isolated from hospital wastewaters were subjected to characterization through antimicrobial susceptibility tests, biofilm formation, multilocus sequence typing (MLST), and PCR analysis for detecting resistance (, , , , , , , , (A), (B), (C), (M), (4⁣'), (6⁣') (2⁣), and (3⁣')) and virulence genes (, , , and ).

Global prevalence of Fusobacterium nucleatum and Bacteroides fragilis in patients with colorectal cancer: an overview of case reports/case series and meta-analysis of prevalence studies.

Background: Colorectal cancer (CRC) is the second deadliest carcinoma across the globe and has been known as a multi-factor induced-disease. Emerging research have demonstrated that bacterial colonization may contribute to the initiation and promotion of the CRC. The presence of Fusobacterium nucleatum (F.

Cliotide U1, a Novel Antimicrobial Peptide Isolated From Leaves.

Aims: Antibiotic resistance is currently a major challenge to scientists. Thus, attempts have been made to develop new compounds with antimicrobial activity. In this research, a new antimicrobial peptide with antibacterial activity was isolated from the plant .

Antiviral and antibacterial peptides: Mechanisms of action.

Antimicrobial peptides (AMPs) present promising alternatives for addressing bacterial and viral multidrug resistance due to their distinctive properties. Understanding the mechanisms of these compounds is essential for achieving this objective. Therefore, this comprehensive review aims to highlight primary natural sources of AMPs and elucidate various aspects of the modes of action of antiviral and antibacterial peptides (ABPs).

Risk of tuberculosis disease in patients receiving TNF-α antagonist therapy: A meta-analysis of randomized controlled trials.

Introduction: Tuberculosis (TB) risk associated with tumor necrosis factor-alpha (TNF-α) antagonist therapy in patients with autoimmune diseases is a significant concern. This study aims to evaluate the risk of TB disease associated with TNF-α antagonist therapy.

Methods: An extensive search of PubMed/MEDLINE, EMBASE, and the Cochrane CENTRAL databases was conducted to identify randomized controlled trials (RCTs) assessing TB disease risk in patients receiving TNF-α antagonist therapy available until November 1, 2024.

The emerging roles of neuroactive components produced by gut microbiota.

Background: As a multifunctional ecosystem, the human digestive system contains a complex network of microorganisms, collectively known as gut microbiota. This consortium composed of more than 10 microorganisms and Firmicutes and Bacteroidetes are the dominant microbes. Gut microbiota is increasingly recognized for its critical role in physiological processes beyond digestion.

Antibiotic Resistance and Virulence Factors in Clinical Isolates of from Hospitalized Patients in Tehran, Iran.

causes challenging infections in immunocompromised patients, exhibiting increasing resistance to multiple antimicrobials and possessing various virulence genes, including emerging resistance to trimethoprim-sulfamethoxazole. A total of 80 clinical isolates of were collected from multiple hospitals in Tehran, Iran. This study conducted an analysis of antibiotic susceptibility by disc diffusion method and -test assay, resistance and virulence gene frequencies were examined by PCR-sequencing, and multilocus sequencing typing (MLST) was performed for strain typing.

Exploiting immunopotential PAPI-1 encoded type IVb major pilin targeting .

significantly contributes to nosocomial infections and necessitates research into novel treatment methods. For the first time, this research evaluated the immunoprotective potential of recombinant PAPI-1 encoded type IV pili targeting in BALB/C mice. The target sequence was identified, and a PilS2-encoding vector was constructed.

Strain-specific effects of probiotics on depression and anxiety: a meta-analysis.

Introduction: Depression and anxiety are pervasive mental health disorders with substantial global burdens. Probiotics, live microorganisms known for their health benefits, have emerged as a potential therapeutic intervention for these conditions. This systematic review and meta-analysis aim to evaluate the strain-specific effects of probiotics on relieving depressive and anxiety symptoms while elucidating underlying mechanisms.

Phenotypic and genotypic characterization of strains isolated from otitis externa: Emergence of CC30- t019-SCC IV carrying PVL as major genotype.

The increasing emergence of as the primary causative agent of otitis externa has been noted; however, detailed information regarding the molecular characteristics of these strains in Iran remains scarce. The current study aims to investigate both genotypic and phenotypic attributes of strains implicated in ear infections. In the present work, we analyzed 60  strains isolated from cases of otitis externa over a period of 45 months.

Investigating the Antimicrobial Effects of a Novel Peptide Derived From Listeriolysin S on , and : An In Silico and In Vitro Study.

Aims: The emergence of antibiotic resistance is one of the most significant issues today. Modifying antimicrobial peptides (AMPs) can improve their effects. In this study, the active region of Listeriolysin S (LLS) as a peptidic toxin has been recognized, and its antibacterial properties have been evaluated by modifying that region.

Rosmarinic Acid Protects the Testes of Rats against Cell Phone and Ultra-high Frequency Waves Induced Toxicity.

Background: Cell phone and Ultra-High Frequency (UHF) waves produce oxidative stress and cause testicular toxicity. This investigation was directed to evaluate the effectiveness of Rosmarinic Acid (RA) against oxidative stress caused by UHF radiation in rats.

Methods: Forty-two male Wistar rats were divided into six groups.

A laboratory-based cross-sectional study about helicobacter pylori infection and diabetes.

Background: Despite the numerous articles discussing the relationship between diabetes mellitus type 2 (DMT2) and chronic Helicobacter pylori (H. pylori) infection the results have been inconsistent, necessitating further research. This study investigated the coexistence of Helicobacter pylori infection and DMT2.

Association between colorectal cancer, the frequency of Bacteroides fragilis, and the level of mismatch repair genes expression in the biopsy samples of Iranian patients.

Background: Deficient DNA mismatch repair (MMR) can cause microsatellite instability (MSI) and is more common in colorectal cancer (CRC) patients. Understanding the carcinogenic mechanism of bacteria and their impact on cancer cells is crucial. Bacteroides fragilis (B.

Multidrug-resistant tuberculosis in Iran: a multicenter study.

The worldwide incidence of multidrug-resistant tuberculosis (MDR-TB) is rapidly increasing, and it has emerged as a pressing public health issue in Iran. Nevertheless, there is a scarcity of up-to-date research on the prevalence of MDR-TB in individuals with pulmonary TB in the country. In this cross-sectional study, we gathered a total of 1216 respiratory samples, each corresponding to a unique patient, from five distinct regional TB laboratories in Iran.

Emerging Challenges in Bloodstream Infections: Insights from Coagulase Typing, Toxin Genes, and Antibiotic Resistance Patterns.

Background: The incidence of complications and mortality associated with () bloodstream infections has been increasing significantly, particularly in developing countries where control strategies against this virulent pathogen and its resistance to antibacterial agents are insufficient. The aim of this study was to investigate coagulase typing, the prevalence of toxin genes, and the antibiotic resistance profile of isolated from bloodstream infections.

Methods: Antibiotic susceptibility of the isolates was determined by the disk diffusion method.

Comparison of the Effects of Rosmarinic Acid and Electromagnetic Radiation-Induced Cardiotoxicity on Rats.

Background: Electromagnetic radiation (EMR) causes stable aggregation of reactive oxygen species (ROS), producing oxidative stress. Rosmarinic acid (RA), a plant-origin antioxidant, has been proposed against the side effects of cell phone and ultrahigh-frequency waves.

Methods: Forty-two male Wistar rats were randomly divided into 6 groups.

Protective potential effects of hydroalcoholic extract of L. (Lamiaceae) against paraquat-induced lung fibrosis: An experimental study in rats.

Objective: Paraquat (PQ) is a highly toxic herbicide that causes pulmonary fibrosis (PF), and no specific antidote is available against it. L. is a plant that exhibits antioxidant and anti-inflammatory activities.