Evidence for Similar Collectivity of High Transverse-Momentum Particles in p-Pb and Pb-Pb Collisions.

Charged hadron elliptic anisotropies (v_{2}) are presented over a wide transverse momentum (p_{T}) range for proton-lead (pPb) and lead-lead (PbPb) collisions at nucleon-nucleon center-of-mass energies of 8.16 and 5.02 TeV, respectively.

A comparative study of patient and provider priorities for cesarean delivery anesthesia care.

Introduction: Patient priorities for anesthesia during a cesarean delivery are not well defined. Previous studies have explored patient preferences for cesarean delivery anesthesia but have not evaluated patient-centered endpoints unrelated to the physical experience which are known to be important to patients' birth experiences, such as being treated with respect, communication, and emotional support. The purpose of this study was to compare patients' and providers' priorities for cesarean delivery anesthesia care.

Cues and Clues: How Humor Targets Classify Joker Intent.

While both prosocial teases and aggressive jokes are characterized by a humorous provocation, a tease is intended to communicate face-protective information or general affiliation while an aggressive joke is intended to socially demean the target. Thus, when targeted by a joke, people must judge whether the intention behind the joke is affiliative or aggressive. To interpret the intention behind a joke, the target must consider information such as "off-record marker" usage and the reputation of the joker.

Improving cosmological reach of a gravitational wave observatory using Deep Loop Shaping.

Improved low-frequency sensitivity of gravitational wave observatories would unlock study of intermediate-mass black hole mergers and binary black hole eccentricity and provide early warnings for multimessenger observations of binary neutron star mergers. Today's mirror stabilization control injects harmful noise, constituting a major obstacle to sensitivity improvements. We eliminated this noise through Deep Loop Shaping, a reinforcement learning method using frequency domain rewards.

Effect of metoclopramide on gastric volume and nausea and vomiting in fasted patients undergoing elective cesarean delivery: a randomized clinical equivalence trial.

Background: The American Society of Anesthesiologists Practice Guidelines for Obstetric Anesthesia recommend preoperative fasting and aspiration prophylaxis including non-particulate antacids, H-receptor antagonists, and/or metoclopramide for elective cesarean deliveries. This study evaluated the effect of metoclopramide on gastric volume in appropriately fasted patients undergoing elective cesarean delivery.

Methods: We conducted a single-center, randomized, placebo-controlled equivalence trial of appropriately fasted patients presenting for elective cesarean delivery.

Search for a Neutral Gauge Boson with Nonuniversal Fermion Couplings in Vector Boson Fusion Processes in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for a heavy neutral spin-1 gauge boson (Z^{'}) with nonuniversal fermion couplings produced via vector boson fusion processes and decaying to tau leptons or W bosons is presented. The analysis is performed using LHC data at sqrt[s]=13  TeV, collected from 2016 to 2018 with the CMS experiment and corresponding to an integrated luminosity of 138  fb^{-1}. The data are consistent with the standard model predictions.

Bilateral subdural hygromas following dural puncture.

A parturient reported a headache 20 hours following unintentional dural puncture during epidural placement for labour analgesia. It was positional, mild to moderate in severity with no focal neurological signs. Six days later, the headache became more severe.

Increasing Access and Availability of Nutrient-Dense Foods at United States Marine Corps Food Venues Is Feasible and Profitable.

: Military Service Members (SMs) require optimal nutrition to support health, readiness, and job performance. However, they often fall short of meeting nutrition guidelines. This study aimed to determine the impact and feasibility of implementing the U.

Inter- and intra-rater agreement among novices and comparison to an experienced consensus using the Gächter scale for the evaluation of septic joints.

Introduction: The purpose of this retrospective study was to determine the inter-and intra-rater agreement among novice raters, as well as agreement between novice raters and an experienced consensus using the Gächter grading scale for the evaluation of the severity of septic joints in dogs.

Methods: Three surgical residents served as novice raters, and two American College of Veterinary Surgery (ACVS) diplomates, experienced with arthroscopic evaluation of canine joints, served as the experienced consensus. Arthroscopy images were first evaluated by the experienced consensus and scored using the Gächter scale.

Inter- and intra-bacterial strain diversity remains the "elephant in the (living) room".

Acinetobacter baumannii is an opportunistic Gram-negative bacterial pathogen responsible for severe nosocomial infections worldwide. Resistance to last-resort antibiotics causes A. baumannii to be ranked as a top priority for the research and development of new antibiotics by the WHO and an urgent threat to public health by the CDC.

Bacterial vaginosis toxins impair sperm capacitation and fertilization.

Study Question: What effect do toxins produced by bacterial vaginosis (BV) bacteria have on sperm function?

Summary Answer: BV toxins dysregulate sperm capacitation and intracellular calcium homeostasis, and impair the ability of sperm to fertilize oocytes.

What Is Known Already: In BV, which is linked to infertility, overgrowth of Prevotella and Gardnerella in the vagina is accompanied by elevated concentrations of the toxins lipopolysaccharide (LPS) and vaginolysin (VLY).

Study Design, Size, Duration: This was a laboratory study in which human semen samples were collected from consenting healthy donors with normal semen parameters.

A Multilateral Qualitative Study of Perspectives on Enhancing Clinical Trial Diversity Among Historically Underrepresented Groups.

Purpose: Clinical trial enrollment among underrepresented patient populations remains a critical challenge in biomedical research. This study was conducted for a clinical trial designed to identify biomarkers that would help predict the transition from acute to chronic pain. Specifically, the purpose of this study was to understand the perspectives of multiple stakeholders to characterize the factors that contribute to underrepresented patients' decisions to participate in the trial and inform actionable strategies that can improve trial recruitment and retention.

Personal Spirituality is Correlated With Psychological Resilience in a Training Marine Population.

Introduction: Spirituality is a recognized component of the DoD Chairman of the Joint Chief of Staff's Total Force Fitness Framework. Although it is often considered akin to religiosity, the Total Force Fitness framework took care to consider components not centered on a theist perspective. Spirituality is considered an adaptive interpersonal characteristic for human flourishing and functioning.

Failure to replace removed growth friendly implants results in deteriorating radiographic outcomes.

Introduction: Management of early onset scoliosis (EOS) patients can require growth-friendly surgery to manage spinal deformity in children too immature for a definitive fusion. There is limited literature on outcomes for patients with failed growing constructs requiring removal of implants (ROI).

Methods: We studied EOS patients from an international registry undergoing removal of growth-friendly implants, comparing early re-implantation (within 12 months of ROI) to observation-only.

Artificial intelligence-driven streamlining of prostate cancer multidisciplinary team recommendations in a tertiary NHS centre in the UK.

Objectives: To evaluate the effectiveness of a rules-based artificial intelligence (AI) clinical decision support system (CDSS) called the PROState AI Cancer-Decision Support (PROSAIC-DS) in streamlining the prostate cancer multidisciplinary team (MDT) pathway by identifying patients meeting standard of care (SoC) guidelines for reduced discussion in MDT meetings.

Subjects/patients And Methods: This study consisted of two phases. Phase one involved a retrospective concordance analysis of 287 patients referred to the prostate MDT at King's College Hospital over a 2-year period.

Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mice.

Introduction: Low back pain affects around 619 million people globally and is the most prevalent musculoskeletal condition worldwide. Low back pain is often difficult to treat with traditional drug combinations, and opioids are prescribed for up to 60% of patients with debilitating low back pain. This study aimed at characterizing the analgesic effect of (2R,6R)-Hydroxynorketamine, an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor dependent analgesic agent, alone or in combination with meloxicam in a murine lumbar disk puncture model.

Restricted Mating Windows and Thrombospondin 2 Gene Deletion Improve the Precision of Parturition Timing in Mice.

Mice are an important model organism for studying reproduction, parturition timing, and embryonic development. Previous reports indicate that limiting mouse breeding periods can reduce variability in fetal weight. To expand on these findings, this study sought to determine whether a restricted breeding window affects mating receptivity, precision of parturition timing, and pregnancy outcomes compared to standard overnight breeding of two common wild-type strains (C57BL/6 J and CD-1) of laboratory mice.

Unmet Needs in Acute Ischemic Stroke: Overcoming Recalcitrant Clots.

Endovascular thrombectomy has revolutionized acute ischemic stroke treatment, significantly improving recanalization rates. However, up to 20% of cases involve recalcitrant clots that fail to recanalize or require multiple passes, negatively impacting clinical outcomes. This review explores the multifaceted nature of these challenging clots, including insights from preclinical, imaging, and clinical studies, with strategies to overcome them.

Registered Dietitian Nutritionist Consultation Is Associated With Improvement in Nutritional Status in Chronically Ill Children: A Retrospective, Cohort Study.

Background: The influence of care provided by a registered dietitian nutritionist (RDN) to malnourished children is not well described.

Objective: To compare nutrition outcomes of malnourished, chronically ill children with and without RDN involvement in outpatient care.

Design: Retrospective cohort study of malnourished children who had ≥1 complex chronic condition with a follow-up period of at least 2 years during which improvement in body mass index-for-age z score (BMIz) and clinical outcomes were assessed.

Fomite advice for scabies: a review of online resources.

Scabies is a significant global public health issue that affects 200 million people worldwide. We reviewed English language, publicly available online resources concerning the management of scabies for guidance on fomites. Information was collected from 10 resources in March 2024.

Reweighting simulated events using machine-learning techniques in the CMS experiment.

Data analyses in particle physics rely on an accurate simulation of particle collisions and a detailed simulation of detector effects to extract physics knowledge from the recorded data. Event generators together with a geant-based simulation of the detectors are used to produce large samples of simulated events for analysis by the LHC experiments. These simulations come at a high computational cost, where the detector simulation and reconstruction algorithms have the largest CPU demands.

Pseudomonas aeruginosa clinical isolates can encode plastic-degrading enzymes that allow survival on plastic and augment biofilm formation.

Multiple bacteria encoding plastic-degrading enzymes have been isolated from the environment. Given the widespread use of plastic in healthcare, we hypothesized that bacterial clinical isolates may also degrade plastic. This could render plastic-containing medical devices susceptible to degradation and failure and potentially offer these pathogens a growth-sustaining substrate, enabling them to persist in the hospital-built environment.

Influence of boundary conditions and blood rheology on indices of wall shear stress from IVUS-based patient-specific stented coronary artery simulations.

The long-term clinical efficacy of coronary stents is limited by restenosis. Coronary stenting results in altered arterial geometry, local blood flow patterns, and wall shear stress (WSS), all of which can influence restenosis. Computational fluid dynamics (CFD) simulations employ assumptions about blood properties and boundary conditions, which also influence WSS alterations from stenting.

Galleria mellonella as a drug discovery model to study oxidative stress.

Biological systems are equipped with endogenous antioxidant defence mechanisms against reactive oxygen species (ROS). Accumulation of ROS usually overwhelms this, creating pathologic effects. Oxidative toxicity has been reported as a causative factor in neurodegenerative diseases, cancer and diabetes mellitus (DM).

Shilla Growth Guidance Surgery for Early Onset Scoliosis: Predictors of Optimal Versus Suboptimal Performers.

Background: The Shilla Growth Guidance surgery (SGGS) aims to correct a child's spinal deformity while allowing continued spinal growth. Our study used a multicenter early-onset-scoliosis database to determine significant predictors of best candidates.

Methods: The Pediatric Spine Study Group multicenter database was analyzed for all patients who had undergone SGGS and had a minimum follow-up of 2 years.