Publications by authors named "Matthieu Opitz"
The bone marrow (BM) is a complex microenvironment in which hematopoietic stem and progenitor cells (HSPCs) interact with multiple cell types that regulate their quiescence, growth, and differentiation. These cells constitute local niches where HSPCs are confined and subjected to specific set of physical and biochemical cues. Endothelial cells forming the walls of blood capillaries have been shown to establish a vascular niche, whereas osteoblasts lying along the bone matrix organize the endosteal niche with distinct and specific impact on HSPC fate.
View Article and Find Full Text PDFFAT1, which encodes a protocadherin, is one of the most frequently mutated genes in human cancers. However, the role and the molecular mechanisms by which FAT1 mutations control tumour initiation and progression are poorly understood. Here, using mouse models of skin squamous cell carcinoma and lung tumours, we found that deletion of Fat1 accelerates tumour initiation and malignant progression and promotes a hybrid epithelial-to-mesenchymal transition (EMT) phenotype.
View Article and Find Full Text PDFArticle Synopsis
- - Rett syndrome (RTT) is a rare disorder that causes loss of motor and language skills, as well as cognitive impairment, primarily due to mutations in the MECP2 gene.
- - Research shows that the absence of MECP2 in glial cells negatively affects neurons, but restoring MECP2 in astrocytes in mice improves movement, anxiety, and lifespan.
- - The study found that the drug Epothilone D can restore microtubule transport in astrocytes lacking MECP2 and improve behavior in RTT-affected mice, suggesting potential for innovative treatment.