Publications by authors named "Matthieu Metzelard"
Purpose: Anemia correlates with increased ICU mortality; but the use of erythropoietin (EPO) as a treatment remains debated. We sought to assess EPO use in ICU severe anemia.
Methods: A retrospective single-center study was conducted in four adult ICUs.
Article Synopsis
- Ventilator-associated pneumonia (VAP) frequently affects patients with severe COVID-19 who are on mechanical ventilation, prompting this study to examine how corticosteroids might influence VAP risk.
- A multicenter study analyzed data from 545 patients in 36 ICUs to determine if corticosteroid use impacted VAP incidence, finding that the relationship varied after 48 hours of mechanical ventilation.
- Overall, no significant link was established between corticosteroid treatment and VAP, though the effect seemed to shift over time during the ICU stay.
Article Synopsis
- - This study aimed to compare the incidence of invasive pulmonary aspergillosis (IPA) in critically ill patients with COVID-19 versus those with influenza, using data from a large European cohort that included over 1,000 patients on mechanical ventilation for pneumonia.
- - Results showed that the incidence of putative IPA was significantly lower in the COVID-19 group (2.5%) compared to the influenza group (6%), indicating that COVID-19 patients had a reduced risk for this fungal infection.
- - The study also found that having putative IPA was linked to increased 28-day mortality and longer ICU stays, affirming its severity, but overall the incidence of IPA was low across both patient groups.
Correction to: Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study.
Intensive Care Med
April 2022
Article Synopsis
- Early empirical antimicrobial treatment is common for critically ill COVID-19 patients, and this study looked at how often bacteria were identified in patients with SARS-CoV-2 pneumonia versus those with influenza pneumonia.
- In a study involving 1,050 patients across 36 ICUs, only 9.7% of SARS-CoV-2 patients had bacterial infections identified within the first 48 hours after intubation compared to 33.6% in influenza patients.
- Coinfections in both groups were primarily caused by gram-positive cocci, and while bacterial identification increased the risk of 28-day mortality for SARS-CoV-2 patients, the overall impact on mortality was similar for both conditions.
Background: Patients with SARS-CoV-2 infection are at higher risk for ventilator-associated pneumonia (VAP). No study has evaluated the relationship between VAP and mortality in this population, or compared this relationship between SARS-CoV-2 patients and other populations. The main objective of our study was to determine the relationship between VAP and mortality in SARS-CoV-2 patients.
View Article and Find Full Text PDFRelationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study.
Intensive Care Med
February 2021
Purpose: Although patients with SARS-CoV-2 infection have several risk factors for ventilator-associated lower respiratory tract infections (VA-LRTI), the reported incidence of hospital-acquired infections is low. We aimed to determine the relationship between SARS-CoV-2 pneumonia, as compared to influenza pneumonia or no viral infection, and the incidence of VA-LRTI.
Methods: Multicenter retrospective European cohort performed in 36 ICUs.
COVID-19- versus non-COVID-19-related Acute Respiratory Distress Syndrome: Differences and Similarities.
Am J Respir Crit Care Med
November 2020