Publications by authors named "Matthieu Martinet"
Objectives: Dysregulation of brain leptin signaling contributes to Alzheimer's disease (AD) pathophysiology, but plasma leptin may not accurately reflect central nervous system activity. This study examined the correlation between plasma and cerebrospinal fluid (CSF) leptin levels and their relationship with beta-amyloid (Aβ) and tau biomarkers.
Methods: Cross-sectional analysis of data from cognitively impaired patients from a tertiary memory clinic.
Background: The SorLA protein, encoded by the Sortilin-related receptor 1 (SORL1) gene, is a major player in Alzheimer's disease (AD) pathophysiology. Functional studies demonstrated that SorLA deficiency results in increased production of Aβ peptide, and thus a higher risk of AD. SorLA can be subject to proteolytic shedding at the cell surface, leading to the release of the soluble ectodomain of the protein (sSorLA) in the extracellular space.
View Article and Find Full Text PDFAlzheimer's disease (AD) is associated with early metabolic dysfunction and adiponectin, which may play a pathophysiological role. Adiponectin is implicated in the regulation of energy homeostasis, carbohydrate, and lipid metabolism, as well as in inflammation modulation. The aim of this study was to study whether plasma adiponectin levels were different between patients with AD confirmed by biomarkers and neurological control subjects.
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- The study investigates the relationship between plasma neurofilament light (NfL) protein levels and cognitive impairment across various patient groups, including Alzheimer’s disease and other dementias.
- The research was conducted on 320 patients, measuring NfL levels and assessing cognitive performance, with significant associations found between higher NfL levels and lower cognition, particularly in memory and executive functions.
- Despite noteworthy findings, the clinical application of plasma NfL in daily practice for unselected cognitive impairment patients remains largely unaddressed.
Response to the Comment on "Plasma Leptin Is Associated With Amyloid CSF Biomarkers and Alzheimer's Disease Diagnosis in Cognitively Impaired Patients".
J Gerontol A Biol Sci Med Sci
July 2023
Objective: To explore the accuracy of plasma neurofilament light chain (NfL) as a biomarker for diagnosis and staging of cognitive impairment, in a large cohort with of previously diagnosed patients in clinical practice.
Methods: Retrospective, cross-sectional, monocentric study, from a tertiary memory clinic. Patients underwent cerebrospinal fluid core Alzheimer's disease (AD) biomarker evaluation using ELISA or Elecsys methods, and plasma NfL analysis using the single molecule array technology.
Plasma Leptin Is Associated With Amyloid CSF Biomarkers and Alzheimer's Disease Diagnosis in Cognitively Impaired Patients.
J Gerontol A Biol Sci Med Sci
March 2023
Article Synopsis
- Metabolic dysfunction and leptin signaling have been linked to Alzheimer's disease (AD), leading researchers to investigate the connections between plasma leptin levels and various biomarkers related to cognitive impairment.
- The study analyzed data from over 1,000 cognitively impaired patients and found that those diagnosed with AD had significantly lower plasma leptin levels compared to those without amyloid-related issues.
- The results suggest a potential link between leptin metabolism and brain amyloid deposition, indicating that plasma leptin levels might play a role in diagnosing and understanding AD pathophysiology.
Article Synopsis
- The study investigated cerebrospinal fluid (CSF) alpha-synuclein levels to distinguish between Dementia with Lewy Bodies (DLB) and Alzheimer’s disease (AD), as abnormal aggregation of this protein is linked to DLB.
- The results showed significantly lower CSF alpha-synuclein levels in DLB patients compared to those with AD and established a potential diagnostic threshold with high sensitivity and specificity.
- The findings suggest that measuring CSF alpha-synuclein could aid in the early diagnosis of DLB in conjunction with other biomarkers, although it was not associated with specific brain atrophy patterns.
Background: Synaptic dysfunction is an early core feature of Alzheimer's disease (AD), closely associated with cognitive symptoms. Neuregulin 1 (NRG1) is a growth and differentiation factor with a key role in the development and maintenance of synaptic transmission. Previous reports have shown that changes in cerebrospinal fluid (CSF) NRG1 concentration are associated with cognitive status and biomarker evidence of AD pathology.
View Article and Find Full Text PDFCancer-associated fibroblasts (CAF) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Stromal heterogeneity may explain differential pathophysiological roles of the stroma (pro- versus anti-tumoural) in PDAC. We hypothesised that multiple CAF functional subtypes exist in PDAC, that contribute to stromal heterogeneity through interactions with cancer cells.
View Article and Find Full Text PDFAngiogenesis is hallmark of clear cell renal cell carcinogenesis. Anti-angiogenic therapies have been successful in improving disease outcome; however, most patients treated with anti-angiogenic agents will eventually progress. In this study we report that clear cell renal cell carcinoma was associated with vasculogenic mimicry in both mice and human with tumor cells expressing endothelial markers in the vicinity of tumor vessels.
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