Selective host autophagy is induced during the intracellular parasite infection controlling amino acid levels.

Unlabelled: a widespread parasite, has the ability to infect nearly any nucleated cell in warm-blooded vertebrates. It is estimated that around 2 billion people globally have been infected by this pathogen. Although most healthy individuals can effectively control parasite replication, certain parasites may evade the immune response, establishing cysts in the brain that are refractory to the immune system and resistant to available drugs.

Host autophagy is exploited by the intracellular parasite to enhance amino acids levels.

Unlabelled: a widespread parasite, has the ability to infect nearly any nucleated cell in warm-blooded vertebrates. It is estimated that around 2 billion people globally have been infected by this pathogen. Although most healthy individuals can effectively control parasite replication, certain parasites may evade the immune response, establishing cysts in the brain that are refractory to the immune system and resistance to available drugs.

A 7-segment numerical hand-glove/mitten model for predicting thermophysiological responses of the human hand in extremely cold conditions.

A 7-segment and 29-node numerical hand-glove/mitten model was developed to simulate human hand physiological responses in various cold environments. To validate the model, simulated skin temperatures were compared to data from published literature and human trials conducted at -20, -40, and -60 °C. Results demonstrated that the model could reasonably predict cold-induced vasodilation (CIVD) responses at 0 °C temperature.

Duration limits for exposure for the whole body and extremities with a military extreme cold protection clothing ensemble at an ambient temperature of -40°C.

Manual performance and body temperature responses were assessed in a 1-h trial at an ambient temperature (T) of -40°C for 7 male participants (32 ± 14 (mean ± SD) years) wearing a typical military extreme cold protection clothing ensemble. The purpose was to establish duration limited exposure (D) for these conditions, and it was hypothesized that (i) core temperature (T) would remain normothermic, whereas extremity skin temperature (T) would decrease; (ii) decrements of manual performance would be in proportion to decreases of hand T; and (iii) D would be determined by the hand or foot T responses. Linear regression was employed to assess associations of manual performance scores and body temperatures with D assessed using the Required Clothing Insulation (I) model and extremity temperatures in ISO 11079-2007.

Towards a continent-wide ecological site condition database using calibrated expert evaluations.

A cost-effective way of undertaking comprehensive, continental-scale, assessments of ecological condition is needed to support large-scale conservation planning, monitoring, reporting, and decision-making. Currently, cross-jurisdictional inconsistency in assessment methods limits the capacity to scale-up monitoring. Here we present a novel way to build a coherent continent-wide site-level ecological condition dataset, using cross-calibration methods to integrate assessments from many observers.

Consecutive non-training days over a weekend for assessing cardiac parasympathetic variation in response to accumulated exercise stress.

To examine the association between day-to-day resting cardiac parasympathetic variability over consecutive non-training days (i.e. weekend) and accumulated exercise stress when quantified using indices of cardiovascular strain.

Belief in the need for sodium supplementation during ultramarathons remains strong: findings from the Ultrarunners Longitudinal TRAcking (ULTRA) study.

In the past, ultramarathon runners have commonly believed that consuming sodium supplements, as capsules or tablets, will prevent exercise-associated hyponatremia (EAH), dehydration, muscle cramping, and nausea, but accumulating evidence indicates that sodium supplementation during ultramarathons is not necessary and may be potentially dangerous. In this work, beliefs about whether sodium supplements should be made available at ultramarathons were assessed during 2018 among 1152 participants of the Ultrarunners Longitudinal TRAcking (ULTRA) study, of which 85.2% had completed an ultramarathon during 2014-2018.

Panting as a human heat loss thermoeffector.

The human autonomic nervous system participates in the control of thermoregulatory responses that are employed to regulate core temperature following deviations of skin temperature and/or core temperature from their respective resting values. This permits a regulation of the core temperature (T) at 37.0 ± 1°C with superimposed circadian variations in both sexes and menstrual cycle-associated variations in premenopausal women.

Efficacy of Hot Yoga as a Heat Stress Technique for Enhancing Plasma Volume and Cardiovascular Performance in Elite Female Field Hockey Players.

Perrotta, AS, White, MD, Koehle, MS, Taunton, JE, and Warburton, DER. Efficacy of hot yoga as a heat stress technique for enhancing plasma volume and cardiovascular performance in elite female field hockey players. J Strength Cond Res 32(10): 2878-2887, 2018-This investigation examined the efficacy of hot yoga as an alternative heat stress technique for enhancing plasma volume percentage (PV%) and cardiovascular performance.

Monitoring the Prescribed and Experienced Heart Rate-Derived Training Loads in Elite Field Hockey Players.

Perrotta, AS, Taunton, JE, Koehle, MS, White, MD, and Warburton, DER. Monitoring the prescribed and experienced heart rate-derived training loads in elite field hockey players. J Strength Cond Res 33(5): 1394-1399, 2019-This study examined the congruence between the prescribed and experienced heart rate-derived training loads over a 5-week periodized mesocycle.

Effect of a patent foramen ovale in humans on thermal responses to passive cooling and heating.

Humans with a patent foramen ovale (PFO) have a higher esophageal temperature (T) than humans without a PFO (PFO-). Thus the presence of a PFO might also be associated with differences in thermal responsiveness to passive cooling and heating such as shivering and hyperpnea, respectively. The purpose of this study was to determine whether thermal responses to passive cooling and heating are different between PFO- subjects and subjects with a PFO (PFO+).

A condition metric for Eucalyptus woodland derived from expert evaluations.

The evaluation of ecosystem quality is important for land-management and land-use planning. Evaluation is unavoidably subjective, and robust metrics must be based on consensus and the structured use of observations. We devised a transparent and repeatable process for building and testing ecosystem metrics based on expert data.

Induction of thermogenesis in brown and beige adipose tissues: molecular markers, mild cold exposure and novel therapies.

Purpose Of Review: The purpose of this short review paper is to summarize recent developments in the understanding of the activation, growth and function of brown adipose tissue (BAT).

Recent Findings: Transcriptional markers for increased BAT activity and differentiation of white adipocytes to 'beige' or 'brite' adipocytes include amongst others peroxisome proliferator-activated receptor γ, cytosine-enhancer-binding protein, positive regulatory domain 16 and bone morphogenetic proteins. These markers induce uncoupling protein 1 expression in brown and 'beige' or 'brite' adipocytes which allows energy from macronutrients to be expended as heat.

Effect of change in ambient temperature on core temperature during the daytime.

In this study, the hypothesis is tested that continuous increases in ambient temperature (Ta) during daytime would give elevated core and skin temperatures, and consequently better thermal sensation and comfort. Rectal temperature (Tre), skin temperatures and regional dry heat losses at 7 sites were continuously measured for 10 Japanese male subjects in three thermal conditions: cond. 1, stepwise increases in Ta from 26 °C at 9 h00 to 30 °C at 18 h00; cond.

Central chemoreflex ventilatory responses in humans following passive heat acclimation.

Since there is temperature dependence of pulmonary ventilation (V˙(E)) in response to the normal modulators (i.e. [Formula: see text] , [Formula: see text] ), it was asked in this study if passive heat acclimation (HA) modifies the human central chemoreflex ventilatory response to CO(2).

Human body temperature and new approaches to constructing temperature-sensitive bacterial vaccines.

Many of the live human and animal vaccines that are currently in use are attenuated by virtue of their temperature-sensitive (TS) replication. These vaccines are able to function because they can take advantage of sites in mammalian bodies that are cooler than the core temperature, where TS vaccines fail to replicate. In this article, we discuss the distribution of temperature in the human body, and relate how the temperature differential can be exploited for designing and using TS vaccines.

The effects of lower body positive and negative pressure on the hypoxic ventilatory decline.

Purpose: Lower body negative pressure (LBNP) augments the acute hypoxic ventilatory response (AHVR) in humans, presumably through altered central integration of baro- and chemoreceptor afferents. This study investigated the effects of LBNP and lower body positive pressure (LBPP) on hypoxic ventilatory decline (HVD) in humans.

Methods: Nine individuals (4 females and 5 males) were tested in a supine position with the lower body supported inside a hypo/hyperbaric chamber.

No effect of skin temperature on human ventilation response to hypercapnia during light exercise with a normothermic core temperature.

Hyperthermia potentiates the influence of CO(2) on pulmonary ventilation (.V(E)). It remains to be resolved how skin and core temperatures contribute to the elevated exercise ventilation response to CO(2).

Adaptation of exercise ventilation during an actively-induced hyperthermia following passive heat acclimation.

Hyperthermia-induced hyperventilation has been proposed to be a human thermolytic thermoregulatory response and to contribute to the disproportionate increase in exercise ventilation (VE) relative to metabolic needs during high-intensity exercise. In this study it was hypothesized that VE would adapt similar to human eccrine sweating (E(SW)) following a passive heat acclimation (HA). All participants performed an incremental exercise test on a cycle ergometer from rest to exhaustion before and after a 10-day passive exposure for 2 h/day to either 50 degrees C and 20% relative humidity (RH) (n = 8, Acclimation group) or 24 degrees C and 32% RH (n = 4, Control group).

Performance of a compact end-tidal forcing system.

The purpose of the present study was to develop and validate a new compact, portable end-tidal forcing (ETF) system capable of reliably controlling end-tidal gases. The system consists of compressed gas sources (air, N(2) and CO(2)) that are connected via three solenoid valves to a humidification chamber and an inspiratory reservoir bag from which the participant breathes. This computer-controlled system compares actual end-tidal gas partial pressures with target pressures and mixes the gases on a breath-by-breath basis.

High-level medium-chain triglyceride feeding and energy expenditure in normal-weight women.

The objective of this study was to assess how short-term feeding of high levels of dietary medium-chain triglyceride (MCT) affect energy expenditure and postprandial substrate oxidation rates in normal-weight, premenopausal women. Eight healthy women were fed both a MCT-rich and an isocaloric long-chain triglyceride (LCT)-rich diet for two 1-week periods separated by a minimum of 21 days. The energy intake in each diet was 45% carbohydrates, 40% fat, and 15% protein.

Influence of passive hyperthermia on human ventilation during rest and isocapnic hypoxia.

The purpose of this study was to examine the potential interaction of core temperature and isocapnic hypoxia on human ventilation and heart rate (HR). In 2 resting head-out water-immersion trials, 8 males first breathed air and then 12% O2 in N2 while the end-tidal partial pressure of carbon dioxide was kept 0.98 (0.