Dendritic Pillar[6]Arenes with Fixed Planar Chirality for Stereoselective Inclusions in Water: A Case of Facile Differentiation of Cocaine Adulterants, Levamisole and Dexamisole.

We describe the preparation, conformational dynamics, and stereoselective recognition characteristics of water-soluble pillar[6]arenes pS-2 and pR-2. These two novel and diastereomeric cavitands comprise a 2,5-bis(ethoxy)pillar[6]arene core with one of six phenylene ring conjugated to two hexaanionic dendrons. Each dendron includes an (S)-glutamic acid amidated with two tris-carboxylic Behera's amines.

Evaluation of -alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors.

Two series of -alkyl isatins and -alkyl indoles varying in size of the alkyl group were synthesised and evaluated for inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Among the -alkyl isatins -, the addition of the -alkyl group improved inhibition potency towards AChE and BChE compared to isatin. Selectivity towards inhibition of BChE was observed, and the increase in size of the -alkyl group positively correlated to improved inhibition potency.