Comparison of Nicotine and Selected Flavorings Content Between Tobacco-Free and Tobacco-Containing Oral Pouches.

Introduction: Flavored oral tobacco-free pouches (ONPs) are novel products that resemble traditional oral tobacco-containing pouches (OTPs) in design and route of administration. However, ONPs contain nicotine, various additives, and a filler material rather than tobacco leaves. Our study compares nicotine content, release, and form, along with selected flavorings content, between brands of ONPs and OTPs.