Publications by authors named "Matteo Piccica"
Human leishmaniasis is facing important epidemiological changes in Southern Europe, driven by increased urbanization, climate changes, emerging of new animal reservoirs, shifts in human behavior and a growing population of immunocompromised and elderly individuals. In this evolving epidemiological landscape, we analyzed the clinical and epidemiological characteristics of human leishmaniasis in the Tuscany region of Central Italy. Through a multicentric retrospective analysis, we collected clinical and demographic data about all cases of leishmaniasis recorded between 2018 and 2023.
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- Injectable cabotegravir and rilpivirine is a new long-acting ART for HIV patients who are already virologically suppressed and stable on other treatments.
- The SCOLTA study aims to document the initial cohort of HIV patients in Italy starting this regimen, looking at adherence to eligibility criteria and their clinical characteristics compared to trial participants.
- Researchers will also investigate early treatment discontinuations to understand better the effectiveness and challenges of this new therapy.
Article Synopsis
- Cefiderocol is an innovative antibiotic showing effectiveness against carbapenem-resistant Gram-negative bacteria, but more postmarketing data was needed to evaluate its real-world use.
- A study involving 142 patients from three Italian hospitals found a 30-day mortality rate of 37%, with comorbidities being a key predictor of poor outcomes, while polymicrobial infections seemed to have a protective effect.
- There was no significant difference in mortality rates between those treated with cefiderocol alone and those given combination therapies, suggesting cefiderocol can serve as a viable monotherapy option.
Objective: Evaluate the real-world accuracy of Myxovirus resistance protein A (MxA) detected by the rapid, point-of-care FebriDx test during the second-wave pandemic in Italy in patients with acute respiratory infection (ARI) and a clinical suspicion of COVID-19.
Design And Methods: Prospective, observational, diagnostic accuracy study whereby hospitalized patients with ARI were consecutively enrolled in a single tertiary care center in Italy from August 1, 2020 to January 31, 2021.
Results: COVID-19 was diagnosed in 136/200 (68.
Rationale For Review: We performed a systematic review of the literature to investigate the efficacy and safety of pentamidine isethionate for the treatment of human tegumentary and visceral leishmaniasis.
Key Findings: A total of 616 papers were evaluated, and 88 studies reporting data on 3108 cases of leishmaniasis (2082 patients with tegumentary leishmaniasis and 1026 with visceral leishmaniasis) were finally included. The majority of available studies were on New World cutaneous leishmaniasis and visceral leishmaniasis caused by Leishmania donovani.
Objectives: Olfactory and gustatory dysfunction (OD/GD) are now recognized as typical symptoms of COVID-19 infection. However, their pathogenesis remains unclear and no clear prognostic factors have been identified. We have analyzed a cohort of mild/moderate hospitalized patients to identify possible clinical or immunological predictors of recovery from OD/GD.
View Article and Find Full Text PDFSeasonal Allergic Rhinitis Symptoms in Relation to COVID-19.
Allergy Rhinol (Providence)
November 2020
Introduction: Mucocutaneous leishmaniasis (MCL) is a complication of tegumentary leishmaniasis, causing potentially life-threatening lesions in the ear, nose, and throat (ENT) region, and most commonly due to Leishmania (Viannia) braziliensis. We report a case of relapsing MCL in an Italian traveler returning from Argentina.
Case Description: A 65-year-old Italian male patient with chronic kidney disease, arterial hypertension, prostatic hypertrophy, and type-2 diabetes mellitus was referred for severe relapsing MCL acquired in Argentina.
We analysed the first 84 coronavirus disease (COVID-19) patients hospitalised in an infectious and tropical disease unit in Florence, Italy, over 30 days after the start of the COVID-19 outbreak in Italy. A 12% reduction in the rate of intensive care unit transfer was observed after the implementation of intensity care measures in the regular ward such as increasing the nurse/patient ratio, presence of critical care physicians and using high flow nasal cannulae oxygenation.
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