Publications by authors named "Matteo Florio Furno"
A new bicyclic polyketide, amesilide (), along with the previously reported metabolites, chamisides A (), B (), and E (), chaetoconvosins B () and C (), and chaetochromins A () and B (), were isolated from the marine fungus MUT6601. The structures of the compounds were determined by extensive spectrometric (HRMS) and spectroscopic (1D and 2D NMR) analyses, as well as specific rotation. Absolute configurations of the stereogenic centers of amesilide () were determined by a comparison of its experimental circular dichroism (CD) spectrum with its time-dependent density functional theory (TD-DFT) electronic circular dichroism (ECD) spectra.
View Article and Find Full Text PDFMarine microplastics (MPs) represent a novel ecological niche, populated by fungi with high potential for pharmaceutical discovery. This study explores the bioactivity of fungal strains isolated from MPs in Mediterranean sediments, focusing on their osteogenic and antiviral activities. Crude extracts prepared via solid-state and submerged-state fermentation were tested for their effects on extracellular matrix mineralization in vitro and bone growth in zebrafish larvae, and for their activity against the respiratory syncytial virus (RSV) and herpes simplex virus type 2 (HSV-2).
View Article and Find Full Text PDFArticle Synopsis
- Fungi play a crucial role in marine ecosystems, yet their diversity and distribution in ocean sediments are not well understood, particularly in relation to microplastics (MPs).
- This study examined fungal abundance and diversity in sediment samples from three locations in the Mediterranean Sea, revealing that many fungal species were newly identified in these marine environments.
- The research highlighted "substrate specificity" in how fungal communities interact with sediments and MPs, suggesting that varying levels of human activity at different sites can significantly impact these fungal populations and overall ecosystem functions.