Publications by authors named "Mathilde Verhoyen"
Article Synopsis
- Senescent cells, previously thought to be in a permanent growth arrest, are now linked to both normal and pathological aging, exhibiting specific biomarkers and gene expression changes due to epigenetic factors.
- Decreased expression of canonical histone deacetylases (HDACs) was observed during the senescence of dermal fibroblasts, and inhibiting HDACs with SAHA or knocking down HDAC2 or HDAC7 leads to increased senescence markers.
- In contrast, reintroducing HDAC7 in pre-senescent fibroblasts enhances their growth potential, indicating that HDACs play a crucial role in regulating the senescence process and may have potential therapeutic applications for promoting healthy aging.
Degeneration of the retinal pigment epithelium (RPE) is a hallmark of atrophic age-related macular degeneration (AMD). Microglia mediated inflammatory responses and oxidative stress are critical pathophysiological processes in the onset and progression of RPE degeneration. Given the central role of the RPE, strategies to protect these cells from damage caused by oxidative stress and inflammation present a promising therapeutic approach to mitigate AMD.
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