Publications by authors named "Mathilde Morisseau"
Background: Prostate cancer is the most common cancer in men aged above 75 years old. Given their heterogeneity, the International Society of Geriatric Oncology recommends using a comprehensive geriatric assessment (CGA) to adapt anticancer treatment management according to their geriatric status. While the theoretical value of this approach is in no doubt, the impact of the CGA on the final therapeutic decision remains elusive.
View Article and Find Full Text PDFThe prognostic value of tumor-infiltrating lymphocytes in vulvovaginal melanoma.
Int J Gynecol Cancer
December 2024
Article Synopsis
- The study aimed to investigate the relationship between the immune microenvironment and survival outcomes in patients with vulvovaginal melanoma.
- It involved a retrospective analysis of 42 patients, examining tumor-infiltrating lymphocytes and genetic mutations, with significant findings on immune cell presence related to better disease-free survival.
- The researchers concluded that specific types of tumor-infiltrating lymphocytes could indicate disease progression and response to treatments, suggesting the need for further multicenter studies to confirm these results.
Article Synopsis
- * It introduces modern analysis techniques that factor in the timing and recurrence of immune-related AEs (irAEs) in cancer patients treated with immune checkpoint inhibitors, based on the MOTIVATE prospective study findings.
- * Results showed variations in the prevalence and timing of irAEs between melanoma and non-small cell lung cancer (NSCLC) patients, leading to more comprehensive safety assessments that can guide clinical and regulatory decisions.
Article Synopsis
- - The study investigates the effectiveness of high-dose-rate (HDR) brachytherapy as an alternative treatment for localized cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) on the face, focusing on local control, survival rates, and quality of life from 2015 to 2021.
- - Out of 67 patients treated, with a majority having early-stage tumors, the local control rate after three years was 87.05%, and most patients experienced only mild side effects like acute radio-mucositis.
- - Quality of life feedback from patients indicated that 77.8% would recommend HDR brachytherapy, underscoring its effectiveness, tolerance, and positive impact on functional outcomes in
Background: Data suggest an association between positron emission tomography/CT (PET/CT) metabolic metrics and tumor microenvironment in several malignancies, and a potential role of PET/CT to monitor response to immunotherapy.
Objective: To evaluate the correlation between tumor loco-regional extension and tumor-infiltrating lymphocyte infiltration in locally advanced cervical cancer prior to concurrent chemo-radiotherapy.The secondary objective was to assess the association between tumor-infiltrating lymphocytes and PET/CT metabolic metrics.
Article Synopsis
- Researchers wanted to see how well a special swallowing test called VFSS can find leaks in the throat after surgery to remove parts of the throat and voice box.
- They looked at 248 patients who had this surgery and took the swallowing test about a week to two weeks later.
- The test was pretty good at spotting leaks; it helped prevent future problems for many patients who had a positive test result.