Publications by authors named "Mathilde M Lecuit"
Article Synopsis
- Metagenomic next-generation sequencing (mNGS) was utilized to study patients with primary or secondary immune deficiencies (PIDs and SIDs) who exhibited immunopathological issues.
- The study involved 30 symptomatic and 59 asymptomatic patients, with mNGS revealing Aichi virus (AiV) in tissue from some infected patients, confirming the potential link between AiV and immunodysregulation.
- Results showed that AiV was associated with significant clinical symptoms, including multiorgan involvement, and symptoms improved after treatment, supporting the idea that AiV may be a causal factor in these patients.
Late-onset enteric virus infection associated with hepatitis (EVAH) in transplanted SCID patients.
Quentin Riller
,
Jacques Fourgeaud
,
Julie Bruneau
,
Suk See De Ravin
,
Grace Smith
,
Mathilde M Lecuit
J Allergy Clin Immunol
June 2023
Article Synopsis
- Allogenic hematopoietic stem cell transplantation (HSCT) and gene therapy (GT) are potential cures for severe combined immunodeficiency (SCID), but patients often face late-onset issues like persistent hepatitis.
- A study of SCID patients revealed that 11 out of 44 experienced persistent hepatitis linked to chronic enteric viral infections, particularly enteric viruses not found in non-hepatitis SCID patients.
- Treatments like retransplantation or gene therapy showed promise, as 5 patients achieved remission of hepatitis and viral clearance, highlighting the importance of addressing immune dysregulation in these patients.