Publications by authors named "Mathilde M Almekinders"
Article Synopsis
- * Researchers created models using mice to study 115 cases of DCIS, helping them discover important signs that can indicate whether a case is high-risk.
- * The study found that certain traits in DCIS, like being high grade or having specific genetic changes, suggest a higher chance of becoming invasive cancer, and they built a collection of 19 models for further research.
Article Synopsis
- Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer, making up 25% of all cases detected through screening.
- Many patients with DCIS may never experience symptoms or require treatment, leading to concerns about overtreatment.
- The article reviews current knowledge on DCIS biology, highlights challenges in distinguishing low-risk from high-risk cases, and discusses the need for better information to tailor treatments appropriately.
Article Synopsis
- The study focused on ductal carcinoma in situ (DCIS) and the need to differentiate harmless lesions from those that could become invasive breast cancer.
- Using a Dutch cohort of over 10,000 women with DCIS, researchers analyzed the immune microenvironment and its characteristics in relation to subsequent invasive breast cancer.
- Results showed that while certain immune cell densities correlated with cancer characteristics, they did not predict the transition to invasive cancer in the observed patients.
Objectives: We aimed to determine the presence, amount and origin of microchimerism in peripheral blood of pregnant and non-pregnant parous women with systemic lupus erythematosus (SLE) as compared to control subjects.
Methods: We performed a comparative study in which peripheral blood was drawn from eleven female non-pregnant SLE-patients and 22 control subjects, and from six pregnant SLE-patients and eleven control subjects during gestation and up to six months postpartum. Quantitative PCR for insertion-deletion polymorphisms and null alleles was used to detect microchimerism in peripheral blood mononuclear cells and granulocytes.
Prognostic value of histopathological DCIS features in a large-scale international interrater reliability study.
Breast Cancer Res Treat
October 2020
Purpose: For optimal management of ductal carcinoma in situ (DCIS), reproducible histopathological assessment is essential to distinguish low-risk from high-risk DCIS. Therefore, we analyzed interrater reliability of histopathological DCIS features and assessed their associations with subsequent ipsilateral invasive breast cancer (iIBC) risk.
Methods: Using a case-cohort design, reliability was assessed in a population-based, nationwide cohort of 2767 women with screen-detected DCIS diagnosed between 1993 and 2004, treated by breast-conserving surgery with/without radiotherapy (BCS ± RT) using Krippendorff's alpha (KA) and Gwet's AC2 (GAC2).
Ductal carcinoma in situ (DCIS) is considered a potential precursor of invasive breast carcinoma (IBC). Studies aiming to find markers involved in DCIS progression generally have compared characteristics of IBC lesions with those of adjacent synchronous DCIS lesions. The question remains whether synchronous DCIS and IBC comparisons are a good surrogate for primary DCIS and subsequent IBC.
View Article and Find Full Text PDFDuctal carcinoma (DCIS) is treated to prevent progression to invasive breast cancer. Yet, most lesions will never progress, implying that overtreatment exists. Therefore, we aimed to identify factors distinguishing harmless from potentially hazardous DCIS using a nested case-control study.
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