Research Question: What are the opinions of individuals undergoing assisted reproductive technology in France on preconception genetic carrier screening for monogenic Mendelian diseases?
Design: A prospective monocentric study using an anonymous online questionnaire to target patients who underwent a consultation at the Assisted Reproductive Technology (ART) service of the Obstetrics and Reproductive Medicine Department, Foch Hospital, between January 2021 and October 2023.
Results: Of the 7793 patients successfully contacted by email, 1206 responded to the survey, yielding a 15.5% response rate.
Background: Rehabilitation has been shown to enhance patient performance before and after lung transplantation, but limited data exist on its role during the immediate post-transplant phase in critical care units.
Methods: We conducted a single-center retrospective study. All adult patients who underwent bilateral transplantation for cystic fibrosis were included.
Background: Advances in chromatography and mass spectrometry have allowed us to develop a novel technique for measuring intraprostatic hormone concentrations directly on prostate needle biopsies, rather than using traditional punch excision. This has significant clinical implications as intraprostatic dihydrotestosterone and testosterone levels could help monitor prostate growth, neoplasia and castration resistance.
Methods: Patients undergoing radical cystoprostatectomy for bladder cancer were prospectively included.
We investigated using a custom NGS panel of 149 genes the mutational landscape of 64 consecutive adult patients with tyrosine kinase fusion-negative hypereosinophilia (HE)/hypereosinophilic syndrome (HES) harboring features suggestive of myeloid neoplasm. At least one mutation was reported in 50/64 (78%) patients (compared to 8/44 (18%) patients with idiopathic HE/HES/HE used as controls; p < .001).
View Article and Find Full Text PDFPurpose: Post-thoracotomy pain syndrome (PTPS) and chronic postsurgical neuropathic pain (CPNP) were evaluated 4 months after thoracic surgery whether the approach was a posterolateral (PL) incision or the less invasive axillary (AX) one.
Methods: Patients, 79 in each group, undergoing a thoracotomy between July 2014 and November 2015 were analyzed 4 months after surgery in this prospective monocentric cohort study.
Results: More PL patients suffered PTPS (60.