Publications by authors named "Mathilde Grapin"
Background: Extra-renal complications are severe in Shiga toxin-producing E. coli hemolytic uremic syndrome (STEC-HUS), with pericardial effusion being rare and inadequately characterized. This study aimed to describe the clinical and biological data, management strategies, and risk factors associated with pericardial effusion in children with STEC-HUS.
View Article and Find Full Text PDFIntroduction: Spontaneous breathing trial (SBT) is recommended during weaning from mechanical ventilation (MV), but objective and easy tools lack to identify pediatric weaning failure. We aimed to assess whether changes in estimated arterial CO₂ (PaCO₂) derived from transcutaneous measurements (PCO₂) were associated with pediatric weaning failure.
Methods: Children (age 72 h -18 years) with MV > 12 h were continuously monitored using a transcutaneous sensor to estimate PaCO₂ from skin CO₂ tension (PCO₂).
Introduction: Denys-Drash syndrome (DDS) is a rare disease typically associated with a triad of early onset nephrotic syndromes (NS), susceptibility to Wilms tumor (WT), and genitourinary structural defects. DDS is caused by Wilms' tumor suppression gene () variants, with the most frequent variants in exons 8 and 9. This study aimed to evaluate the long-term clinical outcomes and genotype-to-phenotype correlations in a large, multicenter cohort of children with typical DDS.
View Article and Find Full Text PDFBackground: Central venous catheterization is crucial for the perioperative and postoperative management of neonatal cardiac surgery patients. The procedure can be challenging due to the small size of the vessels, and it carries a high risk of morbidity and mortality. The most common sites for catheter insertion are the jugular or femoral veins; however, jugular access is typically avoided in patients with univentricular heart disease.
View Article and Find Full Text PDFArticle Synopsis
- This study looked at kids who had a kidney abscess to see how often they had a problem called vesicoureteral reflux (VUR).
- They found that about 41% of the kids had VUR, which is similar to kids who have kidney infections.
- The study suggests that doctors should think about using a special test called VCUG when kids have kidney abscesses or infections multiple times, especially if there are signs of kidney damage.
Article Synopsis
- A new variant of echovirus 11 has been identified as the cause of nine severe neonatal infections, primarily affecting male infants, with a notable occurrence among twins.
- The affected infants, aged 3-5 days at the time of illness, presented with severe sepsis and liver failure.
- This variant, discovered in France since April 2022, has led to an increase in fatal neonatal enterovirus infections compared to previous years, prompting calls for national and international health alerts.
Renal arcuate vein thrombosis-induced acute kidney injury: a rare multiple-Hit-mediated disease.
Clin Kidney J
February 2023
Article Synopsis
- Renal arcuate vein thrombosis (RAVT) is a rare condition that can cause kidney problems in young adults, but we don’t fully understand how often it happens or why it occurs.
- Researchers looked at five young patients with RAVT found during kidney tests, and they noticed that four of them used a lot of pain medication called NSAIDs, which might be linked to the problem.
- They also found signs of a virus called SARS-CoV-2 in one patient’s kidney, suggesting that this virus could harm blood vessels in the kidneys, making the situation worse.
Background: A precise assessment of glomerular filtration rate is key to delineate the care of children with a solitary functioning kidney (SFK). Data regarding measured GFR (mGFR) in this population is restricted to a single study of 77 individuals, which suggested that a GFR estimation (eGFR) method based on creatinine and cystatin C (eGFR-CKiD2) performed better than Schwartz's equation (eGFR-Schwartz).
Methods: We measured GFR in 210 consecutive adolescents (7 to 22 years old) with an SFK referred to our institution between 2014 and 2019 and in 43 young candidates for kidney donation (18 to 25 years old).