Publications by authors named "Mathilde Duque"
Enhanced identification of spp. using MALDI-TOF mass spectrometry.
J Mass Spectrom Adv Clin Lab
August 2025
Introduction: The genus including clinically isolated species and , has a still underexplored role in clinical microbiology. Despite the clinical relevance of spp., current MALDI-TOF commercial systems fail to differentiate these species.
View Article and Find Full Text PDFObjectives: Morganella are opportunistic pathogens increasingly reported in clinical settings. While their phylogeny has been recently updated, no multilocus sequence typing (MLST) scheme is currently available. Developing a MLST scheme can be challenging due to the absence of a strict definition for housekeeping gene selection.
View Article and Find Full Text PDFBackground: The increasing rates of infections caused by broad-spectrum β-lactamase-producing Enterobacterales is a major public health concern. DHA-type cephalosporinases are a rising cause of expanded-spectrum cephalosporin (ESC) resistance in Enterobacterales. Here, we have developed and validated lateral flow immunoassays (LFIAs) for the detection of the DHA-type cephalosporinases.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers analyzed 275 isolates from various countries using genomic techniques and found three main groups along with a proposed modified taxonomy for the genus.
- * The findings suggest significant genetic diversity among Morganella spp and highlight the importance of monitoring these pathogens' resistance mechanisms for better treatment options.
Objectives: The early identification of carbapenemase-producing Enterobacterales (CPE) is required to prevent their spread and initiate proper therapy. Accordingly, it is crucial to develop efficient algorithms using susceptibility testing results to discriminate non-carbapenemase producers (non-CPE) from those that require complementary tests. In 2022, to adapt its recommendations to the evolution of CPE epidemiology (increased prevalence of OXA-244 producers), the Antibiogram Committee of the French Society of Microbiology (CA-SFM) proposed a new algorithm for the screening of CPE.
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- Modified low-density lipoproteins (LDL) can get inside immune cells called macrophages, making them turn into foam cells, which can cause heart problems.
- Mitochondria, the powerhouses of cells, need to work properly to help prevent foam cell formation by moving cholesterol out of macrophages.
- The study found that different types of modified LDL impact mitochondria in different ways, with one type causing damage and the other allowing the cells to adapt while still producing energy.