Publications by authors named "Mathieu Alonso"
Background: Cr-EDTA and Tc-DTPA clearances are two reference methods of determining the glomerular filtration rate. The study aimed to compare these two radioisotopic clearance measurements using an original approach based on population pharmacokinetics in oncopediatrics.
Methods: Plasma concentrations of Cr-EDTA and Tc-DTPA obtained from, respectively, 40 and 19 children treated with nephrotoxic chemotherapy were simultaneously analyzed while accounting for three covariates (i.
Amid the early 2020 SARS-CoV-2 crisis, severe hand sanitizer shortages led to OMS local production recommendations, inviting a diverse array of alcohol producers to contribute. However, not all followed mandatory controls for API-grade alcohol. We conducted a study to ensure the safety of the received alcohols, focusing on methanol and acetaldehyde levels.
View Article and Find Full Text PDFPET Study of Microglial Activation in Kleine-Levin Syndrome.
Neurol Neuroimmunol Neuroinflamm
July 2024
Article Synopsis
- Kleine-Levin syndrome (KLS) is a rare disorder characterized by recurring episodes of excessive sleepiness and cognitive/behavioral issues, potentially linked to inflammation, prompting a study on microglia activation using PET imaging.
- Researchers conducted PET scans on KLS patients and controls, focusing on specific brain regions to measure microglial activation and compare conditions during symptomatic and asymptomatic phases.
- The study found no significant differences in microglial activation between KLS patients and controls or between symptomatic and asymptomatic periods, suggesting a lack of neuroinflammation in KLS and indicating the need for further research on potential biomarkers.
Article Synopsis
- Narcolepsy type 1 (NT1) is linked to the loss of orexin-producing neurons in the hypothalamus, potentially due to an immune response, but past studies showed no inflammation during later stages of the disease.
- This research investigated microglia density in the hypothalamus and thalamus of NT1 patients using PET imaging, compared to control subjects, while also exploring relationships between microglial activity and disease factors like duration and severity.
- Results indicated no significant differences in microglial density between NT1 patients and controls in the hypothalamus and thalamus, but lower overall brain microglial activity was observed in NT1 patients, raising questions about the disease's immune mechanisms and its onset
We recently proposed an equation to estimate the glomerular filtration rate (GFR) in children with cancer based on plasma cystatin C and serum creatinine levels together with body weight (the "CysPed equation"). The current clinical study reports a prospective evaluation of this equation in 18 children treated by nephrotoxic chemotherapy. The CysPed equation resulted in less bias and greater precision compared to two equations previously proposed equations by Schwartz, with or without plasma cystatin C.
View Article and Find Full Text PDFPlasma cystatin C is a marker of renal glomerular injury in children treated with cisplatin or ifosfamide.
Pediatr Blood Cancer
January 2021
Background: Plasma cystatin C is a potential marker of the glomerular filtration rate (GFR), and urinary cystatin C has been proposed as a marker of tubular dysfunction.
Procedure: A prospective study (NCT02822404) was conducted to assess the benefit of considering cystatin C plasma and urinary levels to better evaluate cisplatin and/or ifosfamide renal toxicity in children with cancer. Plasma Cr-EDTA clearance as a marker of GFR and urinary markers of tubular toxicity were monitored in 40 children treated by cisplatin and/or ifosfamide.
Article Synopsis
- - The study examines the biodistribution, metabolism, and radiation dosimetry of a new radiotracer, [F]FNM, which targets NMDA receptors and may help investigate neurological and psychiatric diseases using PET/CT imaging in rats.
- - Researchers evaluated the stability of [F]FNM in human plasma and performed PET/CT scans on rats to collect data on organ uptake and determine effective radiation doses for human models.
- - Results indicate [F]FNM is stable in plasma with a 53% free fraction and low metabolism, showing potential for safe use in humans due to its low total effective dose compared to other PET radiotracers.
Introduction: Cell transplantation is an innovative therapeutic approach after brain injury to compensate for tissue damage. To have real-time longitudinal monitoring of intracerebrally grafted cells, we explored the feasibility of a molecular imaging approach using thymidine kinase HSV1-TK gene encoding and [18F]FHBG as a reporter probe to image enzyme expression.
Methods: A stable neuronal cell line expressing HSV1-TK was developed with an optimised mammalian expression vector to ensure long-term transgene expression.
Radiosynthesis of [F]AV1451 in pharmaceutical conditions and its biological characteristics.
Appl Radiat Isot
October 2017
In this study, we describe the radiosynthesis of [F]AV1451 in terms of its pharmaceutical quality and characterise its physical and biological properties. We performed an in vitro serum stability study in fresh human plasma and a plasma protein binding study. The radiochemical yield was 24% (decay corrected), and the product met all regulatory quality requirements.
View Article and Find Full Text PDFIntroduction: The N-methyl-D-aspartate receptor (NMDAr) is an ionotropic receptor that mediates excitatory transmission. NMDAr overexcitation is thought to be involved in neurological and neuropsychiatric disorders such as Alzheimer disease and schizophrenia. We synthesized [(18)F]-fluoroethylnormemantine ([(18)F]-FNM), a memantine derivative that binds to phencyclidine (PCP) sites within the NMDA channel pore.
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