NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity.

Brown adipose tissue (BAT) is a highly specialized thermogenic tissue and plays a critical role in controlling energy expenditure and metabolic homeostasis. BAT dysfunction is associated with body weight gain and metabolic disorders in mice models. Here, we investigated the influence of the NAD-biosynthesis pathway in the control of BAT metabolism and function.

Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment.

Excessive exercise combined with inadequate recovery time may trigger fatigue, performance impairment, and ultimately the overtraining syndrome. The intramyocellular mechanisms involved in the overtraining syndrome remain only partially known. Here, we combined multi-omics analyses from isogenic BXD mouse strains with a mouse model of overtraining and excessive exercise protocol in mice and humans to evaluate the molecular mechanism involved in the performance impairment induced by excessive exercise.

Fluorescence images of skin lesions and automated diagnosis using convolutional neural networks.

In recent years, interest in applying deep learning (DL) to medical diagnosis has rapidly increased, driven primarily by the development of Convolutional Neural Networks and Transformers. Despite advancements in DL, the automated diagnosis of skin cancer remains a significant challenge. Emulating dermatologists, deep learning approaches using clinical images acquired from smartphones and considering patient lesion information have achieved performance levels close to those of specialists.

Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise.

Dysfunction of the adipose tissue metabolism is considered as a significant hallmark of aging. It has been proposed that α-β hydrolase domain containing 5 (ABHD5) plays a critical role in the control of lipolysis. However, the role of ABHD5 in the control of lipolysis during aging or exercise is unknown.

TINU syndrome: review of the literature and case report.

Introduction: Tubulointerstitial nephritis and uveitis syndrome (TINU Syndrome) is an uncommon clinical entity, and the majority of patients are adolescents and young women. The case reported refers to an elderly patient with ophthalmologic symptoms detected earlier than kidney manifestations, being probably the first case described in Brazil.

Case Report: Female patient, 60 years-old, sought medical attention for complaints of "red eye".