Self-healing chitosan/starch hydrogel as carrier of photosensitizers based on polythiophene/boron nitride nanotubes for photodynamic therapy of cancer cells.

Photodynamic therapy (PDT) is a minimally invasive treatment that utilizes photosensitizing agents activated by specific light wavelengths to produce reactive oxygen species, leading to the destruction of targeted cells. However, the efficacy of these photosensitizers is compromised by their limited solubility and stability. Although nanocarriers for photosensitizers such as boron nitride nanotubes (BNNTs) have been investigated for their biocompatibility and stability, their tendency to form large aggregates in aqueous solutions poses a challenge.

LOX-1 Activation by oxLDL Induces AR and AR-V7 Expression via NF-κB and STAT3 Signaling Pathways Reducing Enzalutamide Cytotoxic Effects.

The oxidized low-density lipoprotein receptor 1 (LOX-1) is one of the most important receptors for modified LDLs, such as oxidated (oxLDL) and acetylated (acLDL) low-density lipoprotein. LOX-1 and oxLDL are fundamental in atherosclerosis, where oxLDL/LOX1 promotes ROS generation and NF-κB activation inducing the expression of IL-6, a STAT3 activator. Furthermore, LOX-1/oxLDL function has been associated with other diseases, such as obesity, hypertension, and cancer.