Permethrin disrupts antioxidant defense responses in .

Permethrin, a pyrethroid commonly used to grow crops worldwide, may affect the aquatic environment and show toxicological impact on non-target organisms.Farmed shrimp, , can be included among these organisms since enzymatic antioxidant defense responses were disrupted in gills and hepatopancreas after exposure to this xenobiotic.Phase II biotransformation (Glutathione S-Transferase - GST activity) was affected as well as Acetylcholinesterase - AchE activity.

Erratum: Corretion to "Nonlinear Investigation of Fluorene-Benzothiadiazole Copolymers with Multiphoton Absorption and Highlights as Optical Limiters".

[This corrects the article DOI: 10.1021/acsomega.4c11627.

New Onset Systemic Lupus Erythematous After Kidney Transplant: Case Report.

The diagnosis of new onset autoimmune diseases in kidney transplant patients is challenging with new onset SLE after kidney transplant being a rare condition, with very few cases reported. We describe a case of a kidney transplant patient who, after 9 years presented with intermittent fever and diarrhea, inflammatory migratory polyarthralgia, myalgias, cramps and an erythematous rash in the cleavage area. Immunological testing revealed positive antinuclear antibodies (ANA 1:640), anti-double-stranded DNA antibodies (53.

Intermediate and long-term AKI outcomes in a public health system.

Background: Acute Kidney Injury (AKI) is frequent and is associated with adverse outcomes.

Aims: To analyze the impact of community-acquired and hospital-acquired AKI on in-hospital and five-year post-discharge kidney replacement therapy (KRT) requirement in the pre-COVID era.

Methods: We linked the regional health system database of 419,851 admissions to the regional KRT registry.

[Unmet Challenges in COVID-19 Prevention for Immunocompromised Individuals: A Consensus Analysis from Portugal].

Introduction: The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulted in significant disease burden and mortality. Despite vaccination successes, new virus variants persist, affecting unvaccinated and immunocompromised individuals (ICI) severely. These high-risk groups face elevated mortality and hospitalization rates.

Cross-Cultural Differences in Fear of Death, Emotional Intelligence, Coping with Death, and Burnout Among Nursing Students: A Comparative Study Between Spain and Portugal.

Nursing students often face emotional challenges related to death and dying, affecting their psychological well-being, emotional intelligence, and academic success. Cultural and educational factors may influence how they experience and manage these stressors. This study aimed to compare fear of death, emotional intelligence, coping with death, and academic burnout among second-year nursing students in Spain and Portugal to identify cross-cultural differences.

Exploring In Vitro Mesenchymal Stem Cell Osteodifferentiation via Vibrational Microspectroscopy: A Review.

The application of vibrational microspectroscopy to the study of in vitro mesenchymal stem cells (MSC) osteogenic differentiation is a promising approach towards the understanding of the molecular processes involved in bone fabrication. Both infrared (IR) and Raman microspectroscopies have been applied, with a clear predominance of the latter. Bone marrow MSC have been the target of most studies, followed by those originating from dental/oral and adipose tissues.

Donor Transmission of an Intravascular Large B-Cell Lymphoma in Multiorgan Transplantation: A Case Report From a Rare Pitfall in the Predonation Screening for Donor Disease.

The prevention of donor-transmitted diseases in solid organ transplantation depends on the thorough screening of donors while maintaining a high level of clinical suspicion. The evolution in these practices reduced the incidence of donor-transmitted tumors to minimal and unexpected events. Nevertheless, the recipients of these exceptional transmissions hold significant clinical consequences, challenging decisions, and poor outcomes.

New Chemotherapeutic Approaches to Treatment of Mesenchymal Triple-Negative Breast Cancer-Sensitive and Resistant to Cisplatin: Assessment of Cellular Response by Vibrational Microspectroscopy.

Triple-negative breast cancer (TNBC) is the most aggressive type of breast tumor with the worst prognosis. New chemotherapeutic agents against TNBC are essential, aiming at a higher efficacy regarding cell growth inhibition and decreased angiogenesis and invasiveness coupled to lower acquired resistance and deleterious side effects. In this study, Raman and Fourier Transform Infrared (FTIR) microspectroscopies were applied to assess the impact of a trinuclear palladium-spermidine complex on human healthy and mesenchymal TNBC cells, with the results being compared to the clinically used drug cisplatin.

Trastuzumab Deruxtecan in Previously Treated HER2-Low Metastatic Breast Cancer: Real-World Multicentric Study in the Portuguese Population.

: Breast cancer is the most common malignant neoplasm in women and the leading cause of cancer-related death. Approximately 50% of HER2-negative breast cancers exhibit low expression of this protein (HER2-low). Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate targeting the HER2 receptor which has shown benefit in patients with HER2-low metastatic breast cancer in the DESTINY-Breast04 study.

Effectiveness of Nursing Interventions on Preventing the Risk of Infection in Adult Inpatients: Protocol for a Systematic Review.

Healthcare-associated infections (HAIs) are a major global public health concern, significantly impacting patient safety and healthcare quality. These infections are associated with high morbidity and mortality rates, prolonged hospital stays, and increased healthcare costs. Nurses play a critical role in infection prevention, implementing evidence-based interventions to reduce infection risks.

Pharmacologic properties and inhibitory activity of 6-azasteroids against and .

Although the current multidrug therapy (MDT) for leprosy is very successful, the long treatment duration and the emergence of antibiotic-resistant strains demand for new alternative drugs. One potential target for drug development against pathogenic mycobacteria is their need to degrade host cholesterol during infection. , due to its degenerate genome, has preserved only the first step of cholesterol catabolism, in which cholesterol is oxidized to cholestenone by the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD).

The Rehabilitation of Women Who Have Had a Mastectomy.

: Breast cancer is one of the main causes of mortality among women, and mastectomy has a significant effect on the body image, sexuality and psychology of women. The aim of postmastectomy rehabilitation is to improve functionality, minimize complications and promote well-being and quality of life. : This study aimed to understand the role of nurses specializing in rehabilitation nursing in the rehabilitation of women who have had a mastectomy.

Exercise combined with corticoid/omega-3 therapy positively affected skeletal and cardiac muscles in middle aged mdx mice.

Exercise has an important impact on skeletal muscle quality, emerging as an adjuvant therapy to ameliorate muscle inflammation and fibrosis in Duchenne muscular dystrophy (DMD). The aim of the present study was to investigate the benefit of exercise alone or in association with corticoid and omega-3 therapy in the middle aged mdx mouse model of DMD, Mdx mice (12 months of age) performed treadmill exercise (12.4 m/min, for 15 min, twice a week) for 4 weeks.

UVR regulation of photoprotection in Phaeodactylum tricornutum (Bacillariophyceae): roles of light energy doses.

The ability of diatoms to adapt to variable light conditions such as photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) is crucial for their survival and ecological role. The study aimed to investigate how different doses of UVR regulate the photoprotection mechanism in Phaeodactylum tricornutum. Five treatments were established: Control (PAR only), PAR + UVR D (17.

Nomenclature of renal involvement in diabetes mellitus: unify to manage diversity.

Diabetes mellitus is the most common cause of chronic kidney disease leading to kidney failure and premature death. Over the years, the nomenclature of kidney involvement in diabetes mellitus has evolved, driven both by the understanding that the phenotype may be more diverse than initially thought and by pragmatism. In clinical practice, most patients with diabetes mellitus do not undergo a comprehensive work-up (including kidney biopsy and genetic testing) to exclude the presence or coexistence of additional factors or other kidney diseases.

Mental health-promoting intervention models in university students: a systematic review and meta-analysis protocol.

Background: The transition to higher education represents a demanding adaptation process with several socioeconomic factors involved. Mental health problems among university students have been worsening since the beginning of the COVID-19 pandemic. Our objective is to create scientific evidence about the models of mental health-promoting interventions among higher education students applied in academic environments, as well as their effectiveness.

Rendering the European neutron research landscape.

Neutrons, owing to their unique properties, serve as indispensable probes for investigating the structure and dynamics of materials across various length scales. The scientific community utilizing neutron research infrastructures encompasses a diverse range of disciplines, making it challenging to quantify its scientific and societal impact. To address this challenge, we apply Natural Language Processing (NLP) and machine learning techniques to analyze the scientific output of the European neutron science community.

Chronic musculoskeletal pain and its association with cognitive function and sarcopenia in older adults: Characterization and change over three months.

Pain, cognitive impairment, and sarcopenia share common risk factors and neurophysiological processes, but studies investigating cognition and sarcopenia in older adults with pain are scarce. This study's main aim was to compare cognition and sarcopenia between older adults with and without chronic pain. A secondary aim was to investigate predictors of cognition and sarcopenia at baseline and 3 months while adjusting for confounders.

Self-care in the person with chronic disease: A protocol for a self-care intervention.

Most aging populations report chronic illnesses, which are usually permanent or recurrent, significantly affect well-being and quality of life, require daily and consistent healthcare management, and last more than three months. Improved health outcomes and reduced healthcare costs are associated with self-care in treating chronic illnesses. The aim is to describe a protocol using a self-care intervention in a person with a chronic disease.

Exploring Marine Biomineralization on the Al-Mg Alloy as a Natural Process for In Situ LDH Growth to Improve Corrosion Resistance.

This study provides a detailed characterization of the AA5083 aluminum alloy, surface, and interface over 6 months of immersion in seawater, employing techniques such as SEM/EDX, GIXRD, μ-Raman and XPS. The purpose was to evaluate the evolution of the biomineralization process that occurs on the Al-Mg alloy. By investigating the specific conditions that favor the in situ growth of layered double hydroxide (LDH) during seawater immersion as a result of biomineralization, this research provides insights into marine biomineralization, highlighting its potential as an innovative and sustainable strategy for corrosion protection.

Simulated practice in the development of clinical reasoning in nursing students: A systematic review protocol.

is a pedagogical technique that replicates real-world scenarios in a controlled environment, enabling nursing students to engage in the teaching-learning process actively. While simulated practice is a growing pedagogical strategy, several studies have examined its strengths and limitations. However, evidence of its effectiveness in developing clinical reasoning skills among nursing students still needs to be improved.

Resin composite aggregated S-PRG particles are not superior to non-S-PRG under microcosm biofilm.

This study assessed the effect of composite resins, aggregated or not with S-PRG particles, and the use of toothpaste in controlling demineralization and bacterial growth. Human molars were distributed into 3 groups: control (CT) - sound teeth, Beautifil Bulk Restorative System (aggregated with S-PRG) (BB), Filtek One Bulk Fill (without S-PRG) (FB). Teeth destined for groups BB and FB previously received Class I preparations (4 × 4 × 4 mm), followed by single-increment restorations.

A service ecosystems perspective to explore social prescribing value co-creation for vulnerable young people in NEET situation.

Background: Social prescribing inherently embodies a co-productive nature, particularly within the 'holistic' model facilitated by the pivotal role of Link Workers. Most attention is focused on collecting evidence about the micro-level relationship between Link Workers and their clients. However, little is known about how this co-productive relationship influences or is influenced by value co-creation at different levels, given the involvement of multiple actors in delivering the intervention.

Morbidity and factors associated with frailty in post-COVID-19 elderly patients attended at a reference center.

Objective: To assess the morbidity profile and identify factors associated with frailty syndrome in post-COVID-19 elderly patients treated at the only Reference Center for Elderly Health Care in northern Minas Gerais.

Methods: This is a case series study, utilizing the Clinical-Functional Vulnerability Index-20 (CFVI-20) and Comprehensive Geriatric Assessment (CGA) to characterize and evaluate the health condition of the group. To define the variables associated with frailty, a multivariate analysis was conducted.