Long-term effect of pain history and experimental pain responses on adolescents' quality-of-life: a cohort study.

Pain has been shown to impact quality-of-life, but less is known on whether adverse pediatric pain profiles predict long-term quality-of-life in non-clinical populations. We aimed to (1) assess the association of multisite and chronic musculoskeletal pain with quality-of-life at age 18, and (2) test whether experimental pain responses at age 13 predict future quality-of-life. We used data from the Generation XXI cohort.

Impacts of biodiversity-dependent ecosystem service debts on the safe operating space of social-ecological systems: a theoretical modelling study.

The rapid environmental changes of the Anthropocene create legacy effects that may shape future Earth system responses. One significant legacy effect is the species extinction debt caused by past habitat destruction. As biodiversity underpins ecosystem services vital to human societies, social-ecological systems may, in turn, be subjected to biodiversity-dependent ecosystem service debts.

Is Combined PhacoAhmed Less Effective than Ahmed Surgery Alone? A 5-Year Retrospective Study of Long-Term Effects.

Combined trabeculectomy-phacoemulsification is known to provoke more inflammation and yield a poorer long-term efficacy than trabeculectomy alone. This study evaluates whether a similar trend exists for Ahmed glaucoma valve implantation when performed with or without concurrent phacoemulsification. We retrospectively analyzed 51 eyes from patients who underwent either Ahmed-Alone (n = 25) or PhacoAhmed (n = 26) surgery over a 5-year period.

The Effect of Dominant Land-Cover Transitions in Shaping Trajectories of Global Forest Change.

Land-cover transitions from forest to non-forest land-covers have led to substantial loss and fragmentation of global forests. While average rates of forest change are well studied, less attention has been paid to spatio-temporal trajectories of forest loss and recovery. These trajectories likely differ by land-cover transition types, and may be constrained by the initial amount and spatial arrangement of the non-forest land-cover.

Understanding difficult-to-treat psoriatic arthritis: Data from the Rheumatic Diseases Portuguese Registry.

Objectives: To estimate the proportion and identify predictors of difficult-to-treat (D2T) psoriatic arthritis (PsA).

Methods: A multicentre observational retrospective study was conducted with patients registered in the Rheumatic Diseases Portuguese Registry (Reuma.pt).

Ocular involvement and visual prognosis in juvenile idiopathic arthritis associated uveitis.

Aim: To characterize a Portuguese population of patients with juvenile idiopathic arthritis (JIA) and to evaluate possible associations between clinical factors and ocular involvement.

Methods: Patients diagnosed with JIA in the previous 20y in Hospital Garcia de Orta were included. Data were assessed from Reuma.

Analysis of patellar reflex in Parkinson disease patients after an acupuncture treatment protocol - Case series study.

Introduction: The investigation of rigidity physiology in Parkinson's Disease involves the examination of reflexes. Parkinsonian patients often demonstrate reduced sensitivity in polysynaptic reflexes within the leg extensor muscles, which is correlated with their postural instability. The compensatory mechanisms for impaired proprioceptive reflex function may involve alterations in intrinsic muscle stiffness.

The relationship between lifestyle factors and outcome of treatment with TNFα inhibitors in axial spondyloarthritis - results from 14 European countries.

Objectives: To quantify the influence of lifestyle factors on tumour necrosis factor inhibitor (TNFi) treatment response, in axial spondyloarthritis (axSpA).

Methods: Data on biologics-naïve adults with axSpA were captured from European rheumatology registries. Information on lifestyle factors (smoking, overweight/obesity, and/or alcohol consumption) were identified ± 30 days of commencing their first TNFi.

Interchangeability of patient pain, fatigue and global scores in patients with spondyloarthritis - a registry-based simulation study.

Background: To investigate a patient-level single imputation approach for patient reported outcomes (PROs) that express similar contents or associated PROs, where a PRO whose value is missing at a particular timepoint is substituted by another PRO whose value is available at the same timepoint.

Methods: We performed a simulation study on registry-based spondyloarthritis data to explore the potential interchangeability between the patient pain (PPA) and fatigue (PFA) assessment scores and relevant Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) individual questions, and between PPA, PFA and patient global assessment (PGA). Performance was assessed per imputation method in terms of relative bias and coverage.

Scored Patient-Generated Subjective Global Assessment (PG-SGA) in Brazilian Cancer Patients and Association with Anthropometric Parameters.

Introduction: The Scored Patient-Generated Subjective Global Assessment (PG-SGA) is a multidimensional tool used to assess malnutrition and associated risk factors.

Objective: To evaluate the nutritional status of Brazilian cancer patients hospitalized using the Scored PG-SGA and to examine the correlations with selected nutritional parameters.

Methods: This observational study included 2.

Diffusion of potentially toxic elements from CCA-treated wood into layey and sandy Brazilian soils.

Reforestation wood treated with chromated copper arsenate (CCA) has been a source of soil pollutants. The planar source diffusion method was used to assess the leaching of As, Cu, and Cr ions from CCA-treated wood into soil. The research focused on treated Pine and Eucalyptus wood in clayey and sandy soils.

Rescue in vitro maturation of germinal vesicle oocytes after ovarian stimulation: the importance of the culture media.

Study Question: What are the nuclear and initial developmental outcomes of rescue-IVM oocytes across multiple commercially available media?

Summary Answer: Of the 11 different media tested, Medium K provided the highest rescue rate in the shortest time and elicited the highest normal oocyte activation rate (NOAR).

What Is Known Already: Following ovarian stimulation, 10-15% of the oocytes are immature with about 10% states in prophase I, i.e.

A new gallbladder parasite Ceratomyxa costaecola n. sp. (Cnidaria: Myxosporea) infecting the Goldblotch grouper Epinephelus costae (Serranidae) from Tunisian waters.

A new species of Ceratomyxa Thélohan, 1892 named Ceratomyxa costaecola n. sp. was recorded in the gallbladder of the Epinephelus costae (Steindachner) fish found in the Gulf of Tunis, Tunisia.

Assessing the efficacy of a novel bone conduction tinnitus suppression device: a 30-day pilot study on clinical and audiological outcomes.

Purpose: This pilot study investigated the efficacy of a novel Tinnitus Retraining Therapy (TRT) device utilizing bone conduction white noise generation, in treating tinnitus in a normal hearing population.

Methods: This study was designed as a prospective, single-arm, observational trial in an outpatient clinic at a tertiary referral center, with 30 consecutive normal hearing patients with tinnitus. Tinnitus-specific questionnaires, namely the Tinnitus Handicap Inventory (THI) and Tinnitus Functional Index (TFI), translated and adapted to European Portuguese were administered.

The Istanbul Consensus update: a revised ESHRE/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment.

This European Society of Human Reproduction and Embryology (ESHRE)/Alpha Scientists in Reproductive Medicine (ALPHA) consensus document provides several novel recommendations to assess oocyte and embryo morphology and rank embryos for transfer. A previous ALPHA/ESHRE consensus on oocyte and embryo morphological assessment was published in 2011. After more than a decade, and the integration of time-lapse technology into embryo culture and assessment, a thorough review and update was needed.

The Istanbul consensus update: a revised ESHRE/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment†,‡.

Study Question: What are the current recommended criteria for morphological assessment of oocytes, zygotes, and embryos?

Summary Answer: The present ESHRE/Alpha Scientists in Reproductive Medicine consensus document provides several novel recommendations to assess oocyte and embryo morphology and rank embryos for transfer.

What Is Known Already: A previous Alpha Scientists in Reproductive Medicine/ESHRE consensus on oocyte and embryo morphological assessment was published in 2011. After more than a decade, and the integration of time-lapse technology into embryo culture and assessment, a thorough review and update was needed.

Disparities in the organisation of national healthcare systems for treatment of patients with psoriatic arthritis and axial spondyloarthritis across Europe.

Background: Studies on national policies for biologics are warranted.

Objectives: To map and compare national healthcare set-ups for prescription, start, switch, tapering, and discontinuation of biologic/targeted synthetic disease-modifying antirheumatic drugs (DMARDs) in patients with psoriatic arthritis and axial spondyloarthritis across Europe, and assess the healthcare set-ups in relation to countries' socio-economic status.

Methods: An electronic survey was developed to collect and compare information on national healthcare systems.

Mitochondrial replacement techniques to resolve mitochondrial dysfunction and ooplasmic deficiencies: where are we now?

Mitochondria are the powerhouses of cell and play crucial roles in proper oocyte competence, fertilization, and early embryo development. Maternally inherited mitochondrial DNA (mtDNA) mutations can have serious implications for individuals, leading to life-threatening disorders and contribute to ovarian ageing and female infertility due to poor oocyte quality. Mitochondrial replacement techniques (MRTs) have emerged as a promising approach not only to replace defective maternal mitochondria in patients carrying mtDNA mutations, but also to enhance oocyte quality and optimize IVF outcomes for individuals experiencing infertility.

Evaluating fatty acid profiles in anisakid nematode parasites and adjacent tissue of European hake (Merluccius merluccius): a first insight into local host-parasite lipid dynamics.

Parasitism in fish is a widespread and ecologically significant phenomenon, affecting fish in both wild and aquaculture environments. Comprehending parasitism is essential for managing fish populations, protecting fish health, and preventing human exposure to zoonotic parasites. Understanding lipid dynamics between parasitic organisms and their hosts is crucial for elucidating host-parasite interactions.

Utilization of caries risk assessment tools within the underserved population: a scoping review.

Objectives: Caries Risk Assessment (CRA) tools can be utilised to assess caries risk levels within underserved individuals to provide risk-based caries management. With no previous review mapping the evidence of CRA tools in underserved populations, a scoping review was conducted to provide a comprehensive view of the current literature and the utilisation of CRA tools in underserved populations. The main objectives of this review are as follows: (1) to comprehensively review CRA tools utilised, and (2) to highlight the important findings indicating the oral health status of underserved population subgroups.

Handling of missing component information for common composite score outcomes used in axial spondyloarthritis research when complete-case analysis is unbiased.

Background: Observational data on composite scores often comes with missing component information. When a complete-case (CC) analysis of composite scores is unbiased, preferable approaches of dealing with missing component information should also be unbiased and provide a more precise estimate. We assessed the performance of several methods compared to CC analysis in estimating the means of common composite scores used in axial spondyloarthritis research.

The Proteolytic Activation, Toxic Effects, and Midgut Histopathology of the Cry1Ia Protoxin in (Coleoptera: Curculionidae).

The red palm weevil (RPW; Coleoptera: Curculionidae) is a destructive pest affecting palms worldwide, capable of causing significant economic losses and ecological damage in managed palm ecosystems. Current management heavily relies on synthetic insecticides, but their overuse fosters resistance. (Bt) offers a promising alternative, producing toxins selective against various insect orders, including Coleoptera.

Unmute biodiversity risks of free trade? The EFTA-Mercosur Agreement (Swiss) case study.

Unlabelled: Sustainability and environmental impact assessments of trade and investment agreements need to address biodiversity more effectively. To showcase this, we examined a report, commissioned by Switzerland, on potential environmental impacts and risks of the trade between Switzerland and the Mercosur under the EFTA-Mercosur Free Trade Agreement. Our analysis focuses on chemical pollution, regulatory impact, duty-free precious minerals, deforestation, and greenhouse gas emission to develop a roadmap for (re-)interpreting (muted) risks on biodiversity in light of the Global Biodiversity Framework.

A pilot study of transcriptomic preimplantation genetic testing (PGT-T): towards a new step in embryo selection?

Study Question: Is it possible to predict an euploid chromosomal constitution and identify a transcriptomic profile compatible with extended embryonic development from RNA sequencing (RNA-Seq) data?

Summary Answer: It has been possible to obtain a karyotype comparable to preimplantation genetic testing for aneuploidy (PGT-A), in addition to a transcriptomic signature of embryos which might be suggestive of improved implantation capacity.

What Is Known Already: Conventional assessment of embryo competence, based on morphology and morphokinetic, lacks knowledge of molecular aspects and faces controversy in predicting ploidy status. Understanding the embryonic transcriptome is crucial, as gene expression influences development and implantation.