Cognitive effects of aromatase inhibitors in early breast cancer patients: a prospective study.

Purpose: Several patients undergoing aromatase inhibitors (AIs) for breast cancer (BC) report cognitive difficulties, although studies on the cognitive effects have yielded mixed findings. This prospective study aimed to investigate the impact on cognitive function of adjuvant AIs and the changes over time.

Methods: Patients with diagnosis of early-stage BC, eligible for adjuvant AIs endocrine therapy, underwent comprehensive neuropsychological assessments for the evaluation of several cognitive domains before and after 12 months of therapy.