Publications by authors named "Maria Dorothea Pozonec"
Background: Although Kirsten rat sarcoma virus (KRAS) mutations represent the most frequent oncogenic driver alterations in Caucasian lung adenocarcinoma (LADC) patients, their impact on immune phenotype and tumor morphology is largely unexplored. Here, we investigated the associations between KRAS mutation subtypes, immune landscape, and tumor heterogeneity in surgically treated LADC, with a particular focus on specific tumor growth patterns.
Methods: This study included 87 surgically treated patients with histologically confirmed early-stage LADC.
Article Synopsis
- Small cell lung cancer (SCLC) is aggressive and often spreads to the brain, leading to the consideration of prophylactic cranial irradiation (PCI) as a treatment option.
- Recent developments in immunotherapy offer promising new strategies for managing brain metastases and could potentially replace PCI while minimizing cognitive side effects associated with radiation.
- Understanding the diverse molecular makeup of SCLC and its varying responses to treatment is crucial for developing personalized strategies to improve patient outcomes in the future.