Unlocking the potential of organopalladium complexes for high-grade serous ovarian cancer therapy.

High-Grade Serous Ovarian Cancer (HGSOC) is the most common and lethal subtype of ovarian cancer, known for its high aggressiveness and extensive genomic alterations. Typically diagnosed at an advanced stage, HGSOC presents formidable challenges in drug therapy. The limited efficacy of standard treatments, development of chemoresistance, scarcity of targeted therapies, and significant tumor heterogeneity render this disease incurable with current treatment options, highlighting the urgent need for novel therapeutic approaches to improve patient outcomes.

Increasing the π-Expansive Ligands in Ruthenium(II) Polypyridyl Complexes: Synthesis, Characterization, and Biological Evaluation for Photodynamic Therapy Applications.

Lack of selectivity is one of the main issues with currently used chemotherapies, causing damage not only to altered cells but also to healthy cells. Over the last decades, photodynamic therapy (PDT) has increased as a promising therapeutic tool due to its potential to treat diseases like cancer or bacterial infections with a high spatiotemporal control. Ruthenium(II) polypyridyl compounds are gaining attention for their application as photosensitizers (PSs) since they are generally nontoxic in dark conditions, while they show remarkable toxicity after light irradiation.

Rhenium(I) Tricarbonyl Complexes of 1,10-Phenanthroline Derivatives with Unexpectedly High Cytotoxicity.

Eight rhenium(I) tricarbonyl aqua complexes with the general formula -[Re(CO)('-bid)(HO)][NO] (), where '-bid is (2,6-dimethoxypyridyl)imidazo[4,5-]1,10-phenanthroline (), (indole)imidazo[4,5-]1,10-phenanthroline (), (5-methoxyindole)-imidazo[4,5-]1,10-phenanthroline (), (biphenyl)imidazo[4,5-]1,10-phenanthroline (), (fluorene)imidazo[4,5-]1,10-phenanthroline (), (benzo[]thiophene)imidazo[4,5-]1,10-phenanthroline (), (5-bromothiazole)imidazo[4,5-]1,10-phenanthroline (), and (4,5-dimethylthiophene)imidazo[4,5-]1,10-phenanthroline (), were synthesized and characterized using H and C{H} NMR, FT-IR, UV/Vis absorption spectroscopy, and ESI-mass spectrometry, and their purity was confirmed by elemental analysis. The stability of the complexes in aqueous buffer solution (pH 7.4) was confirmed by UV/Vis spectroscopy.

The beneficial effect of cyclohexyl substituent on the anticancer activity of diiron vinyliminium complexes.

Novel diiron vinyliminium complexes, [FeCp(CO)(μ-CO){μ-η:η-C(R)CHCNMe(R)}]CFSO (2a-f; R = 4-CHOMe, Cy or Me; R = Cy, CHCy or 4-CHOMe; Cy = cyclohexyl, Cp = η-CH), were synthesized by alkyne insertion reaction from the corresponding diiron aminocarbyne precursors, and isolated in 53-98% yields. The reactions of selected vinyliminium complexes with NCHCOEt and MeONa, followed by -methylation, afforded the new hydrazone-vinyliminium [FeCp(CO)(μ-CO){μ-η:η-C(R)C(NMeNCHCOEt)CN(R)(R)}]X (4a-c; R = Me or CHPh; R = Cy, CHPh or Me; R = 4-CHOMe or Ph; X = NO or CFSO), in 53-67% yields. Compounds 2a-f and 4a-c were fully characterized by IR and multinuclear NMR spectroscopy, and the structures of 2a-c were ascertained by single crystal X-ray diffraction.

Three's a crowd - stabilisation, structure, and applications of DNA triplexes.

DNA is a strikingly flexible molecule and can form a variety of secondary structures, including the triple helix, which is the subject of this review. The DNA triplex may be formed naturally, during homologous recombination, or can be formed by the introduction of a synthetic triplex forming oligonucleotide (TFO) to a DNA duplex. As the TFO will bind to the duplex with sequence specificity, there is significant interest in developing TFOs with potential therapeutic applications, including using TFOs as a delivery mechanism for compounds able to modify or damage DNA.

Tethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes.

Four propargyl -glycosides derivatized with mannose, glucose, and fructose moieties were synthesized and then incorporated within a diiron structure as part of a vinyliminium ligand. Hence, six glycoconjugated diiron complexes, []CFSO (see Scheme 1) and the nonglycosylated analogues []CFSO, were obtained in high yields and unambiguously characterized by elemental analysis, mass spectrometry, and IR and multinuclear NMR spectroscopies. All compounds exhibited a significant stability in DMSO- /DO solution, with 63-89% of the complexes unaltered after 72 h at 37 °C and also in the cell culture medium.

Gold(III) to Ruthenium(III) Metal Exchange in Dithiocarbamato Complexes Tunes Their Biological Mode of Action for Cytotoxicity in Cancer Cells.

Malignant tumors have affected the human being since the pharaoh period, but in the last century the incidence of this disease has increased due to a large number of risk factors, including deleterious lifestyle habits (i.e., smoking) and the higher longevity.

Insight into an outbreak of Salmonella Choleraesuis var. Kunzendorf in wild boars.

An unusual mortality of wild boars occurred in Italy from 2012 to 2015 due to Salmonella Choleraesuis infection. In order to confirm the occurrence of an outbreak of S. Choleraesuis in wild boars and to epidemically characterise the unique S.

Molecular characterization of Salmonella enterica serovar 4,[5],12:i:- DT193 ASSuT strains from two outbreaks in Italy.

Salmonella enterica subsp. enterica serovar 4,[5],12:i:- DT193 is recognized as an emerging monophasic variant of Salmonella Typhimurium in many European countries. Resistance to ampicillin, streptomycin, sulphonamides, and tetracycline (R-type ASSuT) is described as one of the most common profiles of resistance within this clone.

Fluoroquinolone resistance detection in Campylobacter coli and Campylobacter jejuni by Luminex xMAP technology.

The proportion of Campylobacter spp. isolates that are resistant to fluoroquinolones, the drugs of choice for campylobacteriosis, has been increasing worldwide. We developed an innovative method based on a Luminex xMAP DNA suspension array that allows the identification of Campylobacter species and, simultaneously, the detection of the most common point mutation in the gyrA gene (substitution from threonine 86 to isoleucine 86) that is responsible for fluoroquinolone resistance.