Smart thin porous calcium phosphate coatings for local antibiotic delivery.

Objective: Implant failure after arthroplasty, primarily due to aseptic loosening or periprosthetic joint infection, remains a significant clinical problem. Bioactive ceramic coatings, such as β-tricalcium phosphate (β-TCP), enhance osseointegration and may reduce the risk of aseptic loosening. At the same time, localized antibiotic release from the implant surface represents a promising strategy to prevent early bacterial colonization.

Biodegradable, Antibacterial TCP Implant Coatings With Magnesium Phosphate-Based Supraparticles.

This work highlights the potential of porous, bioactive coatings to advance implant technology and address critical clinical challenges. A key issue in implant coatings is to achieve the balance between infection prevention and successful osseointegration. Although titanium implants are widely used due to their mechanical strength and biocompatibility, their bioinert nature limits integration with bone tissue.

Investigation of copper doped-TCP and GB14 coatings produced via high velocity suspension flame spraying-a biocompatibility and antimicrobial activity study.

Implant-associated infections and aseptic loosening of prosthesis due to insufficient secondary stability continue to present a challenging issue in arthroplasty. Potential solutions include bioactive coatings to promote osseointegration. With this in mind, this study aims to investigate and compare thin bioactive and bioresorbable-tricalcium phosphate (-TCP) and calcium alka-li orthophosphate (GB14) coatings, both produced via high velocity suspension flame spraying.