Comparison between upper and lower airway microbiome profiles in chronic rhinosinusitis patients.

Background: Dysregulation of the airway microbiota is thought to contribute to airway inflammation in both chronic rhinosinusitis (CRS) and asthma. However, the relationship between the upper and lower airway microbiome remains unclear.

Methods: Sinus and lung brushes were collected from 29 CRS participants undergoing sinus surgery.