Causal mediation analysis: what is it and how can it be used to inform practice and policy?

Background: Causal mediation, a quantitative analysis method, has the potential to be a valuable addition to any primary care provider, researcher, or student's toolbox.

Objective: This manuscript describes the theory behind causal mediation, provides a running example to help understand the application of this method in research, and explains how the results may be applied practically to help design appropriate interventions.

Methods And Application: Causal mediation allows an exploration of the mechanism of action of a primary care intervention on an outcome that may pass through a third variable that is on the causal pathway, a mediator.

The Experience of Caregivers of Older Adults With Dementia in Using Telemedicine in a Primary Care Setting of Canada During COVID-19.

Background: Primary care is essential in dementia management, offering diagnosis, treatment, and support for people living with dementia (PLWD) and their caregivers. Telemedicine became a key advancement during the COVID-19 pandemic, offering crucial access to care. This study explores the pros and cons of telemedicine for dementia care during the pandemic to guide future improvements.

Metabolites from the Dark Septate Endophyte Drechslera sp. Evaluation by LC/MS and Principal Component Analysis of Culture Extracts with Histone Deacetylase Inhibitors.

Secondary metabolites from the cultures of the dark septate fungal endophyte (DSE) Drechslera sp., isolated from the roots of rye grass (Lollium sp.) and cultured under different experimental conditions, are described here for the first time.

[Autologous hematopoietic cell transplantation in patients with multiple myeloma. Experience in 53 patients].

Background: Autologous hematopoietic cell transplantation (THA) in patients with multiple myeloma and amyloidosis is the standard of care to promote disease free survival and quality of life.

Aim: To report our experience with THA in patients with multiple myeloma.

Material And Methods: Retrospective review of the hematopoietic cell transplantation database of a hospital of a Medical School.

The thalloid liverwort Plagiochasma rupestre supports arbuscular mycorrhiza-like symbiosis in vitro.

In the present study, we obtained in vitro dual cultures between the liverwort Plagiochasma rupestre and two arbuscular mycorrhizal (AM) fungi: Glomus intraradices and Glomus clarum. Four agarized culture media were tested for optimal growth of P. rupestre.

[Hairy cell leukemia during pregnancy: report of one case].

Hairy cell leukemia (HCL) is a rare chronic B cell lymphoproliferative disorder that affects mostly men. It usually presents with pancytopenia, splenomegaly and bone marrow infiltration, without lymphadenopathy. Diagnosis is based on the presence of mononuclear cells with cytoplasmic projections in a blood smear, the typical bone marrow infiltration pattern and the immunophenotypic profile.