Publications by authors named "Maria A Ulmer"
Early evidence that patients with (multiple) pre-existing diseases are at highest risk for severe COVID-19 has been instrumental in the pandemic to allocate critical care resources and later vaccination schemes. However, systematic studies exploring the breadth of medical diagnoses, including common, but non-fatal diseases are scarce, but may help to understand severe COVID-19 among patients at supposedly low risk. Here, we systematically harmonized >12 million primary care and hospitalisation health records from ~500,000 UK Biobank participants into 1448 collated disease terms to systematically identify diseases predisposing to severe COVID-19 (requiring hospitalisation or death) and its post-acute sequalae, Long COVID.
View Article and Find Full Text PDFComplex patterns of multimorbidity associated with severe COVID-19 and long COVID.
Commun Med (Lond)
July 2024
Background: Early evidence that patients with (multiple) pre-existing diseases are at highest risk for severe COVID-19 has been instrumental in the pandemic to allocate critical care resources and later vaccination schemes. However, systematic studies exploring the breadth of medical diagnoses are scarce but may help to understand severe COVID-19 among patients at supposedly low risk.
Methods: We systematically harmonized >12 million primary care and hospitalisation health records from ~500,000 UK Biobank participants into 1448 collated disease terms to systematically identify diseases predisposing to severe COVID-19 (requiring hospitalisation or death) and its post-acute sequalae, Long COVID.
Article Synopsis
- * Our findings revealed lower levels of formate and fumarate in individuals with AD, along with decreased microbial secretion of formate in personalized metabolic models.
- * The study highlights that specific genetic reactions linked to AD may affect formate production, suggesting its potential as an early marker and indicating a complex interplay between gut microbiota and AD.