Identification of the Novel HLA-DRB1*07:60:02 Allele by Next-Generation Sequencing.

HLA-DRB1*07:60:02 differs from HLA-DRB1*07:01:01:01 by one nucleotide substitution at codon 44 in exon 2.

PD-L1 plasma cells suppress T lymphocyte responses in patients with sepsis and mouse sepsis models.

Sepsis, a leading cause of death in intensive care units, is associated with immune alterations that increase the patients' risk of secondary infections and mortality, so better understandings of the pathophysiology of sepsis-induced immunosuppression is essential for the development of therapeutic strategies. In a murine model of sepsis that recapitulates immune alterations observed in patients, here we demonstrate that PD-L1CD44B220CD138IgM regulatory plasma cells are induced in spleen and regulate ex vivo proliferation and IFNɣ secretion induced by stimulation of T splenocytes. This effect is mediated both by cell-cell contact through increased PD-L1 expression on plasma cells and by production of a soluble factor.

Identification of the Novel HLA-B*56:102 Allele by Next-Generation Sequencing.

HLA-B*56:102 differs from HLA-B*56:01:01:02 by one nucleotide substitution at codon 240 in exon 4.

Identification of the novel HLA-B*56:100 allele by next-generation sequencing.

HLA-B*56:100 differs from HLA-B*56:20:02 by one nucleotide substitution at codon 147.2 in exon 3.